Overexpression of SEZ6L2 and Immune Infiltration in Cancer Based on Gene Image Diagnosis.

IF 2 4区医学 Q3 DERMATOLOGY Skin Research and Technology Pub Date : 2024-10-01 DOI:10.1111/srt.70096

Liangfu Ding, Jilin Zeng, Junyong Zhao

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Abstract

Background: With the rapid advancement of optical image diagnostic technology, researchers are delving into the potential applications in the field of cancer diagnosis and treatment. The exact link between the SEZ6L2 gene and cancer immune infiltration remains elusive.

Materials and methods: This study aims to investigate the relationship between SEZ6L2 gene overexpression and cancer immune infiltration using optical image diagnostic technology, thereby presenting novel insights for enhancing cancer diagnosis and treatment strategies. Tissue samples obtained from cancer patients were meticulously analyzed to quantitatively assess the expression of the SEZ6L2 gene through light image diagnostic technology. Additionally, immunohistochemical techniques were employed to assess the nature and quantity of immune infiltrating cells within the cancerous tissues.

Results: The enrichment pathways were found to include complement activation, circulating immunoglobulin mediated humoral immune response, protein activation cascade, immunoglobulin complex, and immunoglobulin. In addition, the expression of SEZ6L2 is closely related to the infiltration level of tumor infiltrating immune cells (TIICs), and there is a potential relationship between the expression of SEZ6L2 and different marker genes of TIIC.

Conclusion: Increased SEZ6L2 mRNA expression in breast invasive carcinoma was significantly associated with negative prognosis and immune invasion. SEZ6L2 may be a novel prognostic biomarker and a potential immunotherapeutic target in BRCA.

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基于基因图像诊断的 SEZ6L2 过表达与癌症中的免疫渗透

背景：随着光学图像诊断技术的快速发展，研究人员正在深入研究其在癌症诊断和治疗领域的潜在应用。材料与方法：本研究旨在探讨 SEZ6L2 基因过表达与癌症免疫浸润之间的关系：本研究旨在利用光学图像诊断技术研究 SEZ6L2 基因过表达与癌症免疫浸润之间的关系，从而为加强癌症诊断和治疗策略提供新的见解。研究人员对癌症患者的组织样本进行了细致分析，通过光图像诊断技术对 SEZ6L2 基因的表达进行了定量评估。此外，还采用免疫组化技术评估癌症组织中免疫浸润细胞的性质和数量：结果：发现富集途径包括补体活化、循环免疫球蛋白介导的体液免疫反应、蛋白活化级联、免疫球蛋白复合物和免疫球蛋白。此外，SEZ6L2的表达与肿瘤浸润免疫细胞（TIICs）的浸润水平密切相关，SEZ6L2的表达与TIIC的不同标记基因之间存在潜在的关系：结论：SEZ6L2 mRNA在乳腺浸润癌中的表达增加与预后不良和免疫侵袭显著相关。SEZ6L2可能是一种新的预后生物标志物，也可能是BRCA的潜在免疫治疗靶点。

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来源期刊

Skin Research and Technology 医学-皮肤病学

CiteScore

3.30

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Skin Research and Technology is a clinically-oriented journal on biophysical methods and imaging techniques and how they are used in dermatology, cosmetology and plastic surgery for noninvasive quantification of skin structure and functions. Papers are invited on the development and validation of methods and their application in the characterization of diseased, abnormal and normal skin. Topics include blood flow, colorimetry, thermography, evaporimetry, epidermal humidity, desquamation, profilometry, skin mechanics, epiluminiscence microscopy, high-frequency ultrasonography, confocal microscopy, digital imaging, image analysis and computerized evaluation and magnetic resonance. Noninvasive biochemical methods (such as lipids, keratin and tissue water) and the instrumental evaluation of cytological and histological samples are also covered. The journal has a wide scope and aims to link scientists, clinical researchers and technicians through original articles, communications, editorials and commentaries, letters, reviews, announcements and news. Contributions should be clear, experimentally sound and novel.