{"title":"[Practical guidance for CAR T-cell therapy in adults].","authors":"Toshio Kitawaki","doi":"10.11406/rinketsu.65.1155","DOIUrl":null,"url":null,"abstract":"<p><p>Chimeric antigen receptor (CAR) T-cell therapy is an innovative treatment for B-cell malignancies and multiple myeloma. CAR T-cell therapy is now approved in Japan and has become one of the essential therapeutic options for chemotherapy-resistant disease. It has many unique features that distinguish it from conventional chemotherapies, including the limitations imposed by the production of CAR-T cells from autologous T cells, and the limited availability and mandatory waiting period for treatment. Importantly, each patient has only one opportunity to receive CAR T-cell therapy. To achieve the maximum therapeutic benefit from CAR T-cell therapy, it is necessary to understand all aspects of CAR T-cell therapy, including factors that influence its efficacy. The design of the entire treatment sequence, including before and after CAR T-cell therapy, is also important to optimize clinical outcomes. In addition, since this treatment is only available at a limited number of facilities, effective coordination between local hospitals and treatment centers is also important. This educational session will focus on the practical aspects of CAR T-cell therapy in adults and will provide indispensable knowledge for providing CAR T-cell therapy to patients with B-cell lymphoma and multiple myeloma.</p>","PeriodicalId":93844,"journal":{"name":"[Rinsho ketsueki] The Japanese journal of clinical hematology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"[Rinsho ketsueki] The Japanese journal of clinical hematology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.11406/rinketsu.65.1155","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Chimeric antigen receptor (CAR) T-cell therapy is an innovative treatment for B-cell malignancies and multiple myeloma. CAR T-cell therapy is now approved in Japan and has become one of the essential therapeutic options for chemotherapy-resistant disease. It has many unique features that distinguish it from conventional chemotherapies, including the limitations imposed by the production of CAR-T cells from autologous T cells, and the limited availability and mandatory waiting period for treatment. Importantly, each patient has only one opportunity to receive CAR T-cell therapy. To achieve the maximum therapeutic benefit from CAR T-cell therapy, it is necessary to understand all aspects of CAR T-cell therapy, including factors that influence its efficacy. The design of the entire treatment sequence, including before and after CAR T-cell therapy, is also important to optimize clinical outcomes. In addition, since this treatment is only available at a limited number of facilities, effective coordination between local hospitals and treatment centers is also important. This educational session will focus on the practical aspects of CAR T-cell therapy in adults and will provide indispensable knowledge for providing CAR T-cell therapy to patients with B-cell lymphoma and multiple myeloma.
嵌合抗原受体(CAR)T 细胞疗法是一种治疗 B 细胞恶性肿瘤和多发性骨髓瘤的创新疗法。CAR T 细胞疗法现已在日本获得批准,并已成为化疗耐药疾病的基本治疗方案之一。CAR T 细胞疗法与传统化疗相比有许多独特之处,包括从自体 T 细胞中提取 CAR T 细胞所带来的限制,以及治疗的有限性和强制等待期。重要的是,每位患者只有一次接受 CAR T 细胞治疗的机会。要想从 CAR T 细胞疗法中获得最大的治疗效果,就必须了解 CAR T 细胞疗法的方方面面,包括影响其疗效的因素。整个治疗序列(包括 CAR T 细胞疗法前后)的设计对于优化临床结果也很重要。此外,由于这种疗法只在有限的几家机构提供,当地医院和治疗中心之间的有效协调也很重要。本讲座将重点介绍成人 CAR T 细胞疗法的实际操作,为 B 细胞淋巴瘤和多发性骨髓瘤患者提供 CAR T 细胞疗法不可或缺的知识。