Association between serum level of uric acid in Japanese young patients with coronary spastic angina receiving coronary angiography.

IF 1.4 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Heart and Vessels Pub Date : 2024-10-05 DOI:10.1007/s00380-024-02469-4

Kota Tanazawa, Hidefumi Akioka, Kunio Yufu, Taiki Makita, Hiroki Sato, Yuki Iwabuchi, Yuma Ono, Hirochika Yamasaki, Masaki Takahashi, Naoko Ogawa, Taisuke Harada, Kazuki Mitarai, Nozomi Kodama, Shuichiro Yamauchi, Masayuki Takano, Kei Hirota, Miho Miyoshi, Keisuke Yonezu, Katsunori Tawara, Ichitaro Abe, Hidekazu Kondo, Shotaro Saito, Akira Fukui, Tomoko Fukuda, Tetsuji Shinohara, Kumiko Akiyoshi, Yasushi Teshima, Naohiko Takahashi

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Abstract

Endothelial dysfunction may trigger coronary spastic angina (CSA). However, the risk factors for CSA in young patients remain unclear. This study aimed to investigate the age-dependent role of serum uric acid levels in patients with CSA. We enrolled 423 patients who underwent an ergonovine tolerance test during coronary angiography for the CSA evaluation. We categorized the patients as (1) young (age ≤ 65 years) CSA-positive (n = 33), (2) young CSA-negative (n = 138), (3) elderly (age > 66 years) CSA-positive (n = 42), and (4) elderly CSA-negative (n = 210) groups. In the young groups, the smoker proportion (57.6 vs. 38.4%, p = 0.04) and serum uric acid levels (6.3 ± 1.4 vs. 5.4 ± 1.5 mg/dl, p = 0.006) were significantly higher in the CSA-positive compared with the CSA-negative group. Conversely, in the elderly group, the male proportion (66.6 vs. 47.1%, p = 0.02) and alcohol consumption level (40.5 vs. 21.0%, p = 0.01) were significantly higher in the CSA-positive compared with the CSA-negative group. The multivariate analysis in young groups revealed the independent association between the serum uric acid level (p = 0.02) and the presence of CSA. Our results indicate that elevated serum uric acid levels may affect CSA development in young patients.

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接受冠状动脉造影术的日本年轻冠状动脉痉挛性心绞痛患者血清尿酸水平之间的关系。

内皮功能障碍可能引发冠状动脉痉挛性心绞痛（CSA）。然而，年轻患者发生 CSA 的风险因素仍不清楚。本研究旨在探讨血清尿酸水平在 CSA 患者中的年龄依赖性作用。我们招募了 423 名在冠状动脉造影术中接受麦角新碱耐受试验以评估 CSA 的患者。我们将患者分为：(1) 年轻组（年龄小于 65 岁）CSA 阳性（33 人）；(2) 年轻组 CSA 阴性（138 人）；(3) 老年组（年龄大于 66 岁）CSA 阳性（42 人）；(4) 老年组 CSA 阴性（210 人）。在年轻组中，CSA 阳性组的吸烟者比例（57.6% 对 38.4%，P = 0.04）和血清尿酸水平（6.3 ± 1.4 对 5.4 ± 1.5 mg/dl，P = 0.006）明显高于 CSA 阴性组。相反，在老年组中，与 CSA 阴性组相比，CSA 阳性组的男性比例（66.6% 对 47.1%，p = 0.02）和饮酒水平（40.5% 对 21.0%，p = 0.01）明显更高。年轻组的多变量分析显示，血清尿酸水平（p = 0.02）与 CSA 的存在之间存在独立关联。我们的研究结果表明，血清尿酸水平升高可能会影响年轻患者 CSA 的发生。

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来源期刊

Heart and Vessels 医学-外周血管病

CiteScore

3.10

自引率

13.30%

发文量

211

审稿时长

2 months

期刊介绍： Heart and Vessels is an English-language journal that provides a forum of original ideas, excellent methods, and fascinating techniques on cardiovascular disease fields. All papers submitted for publication are evaluated only with regard to scientific quality and relevance to the heart and vessels. Contributions from those engaged in practical medicine, as well as from those involved in basic research, are welcomed.