Hematopoietic Stem Cell Transplantation in the Management of Myelodysplastic Syndrome: A Retrospective, Current, and Future Perspective.

IF 3.2 4区医学 Q3 CELL & TISSUE ENGINEERING Cell Transplantation Pub Date : 2024-01-01 DOI:10.1177/09636897241284283

Qimudesiren, Wenjie Yin, Yuhong Wang, Guo Qing, Jinhua Bao, Chaomurilige, Shana Chen, Liren Qian

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Abstract

Myelodysplastic syndrome (MDS) is a clonal disorder that affects hematopoietic stem cells (HSCs), primarily occurring in the elderly population. Lower-risk MDS is characterized by a decrease in blood cells, whereas higher-risk MDS is associated with an increased risk of transformation to acute myeloid leukemia (AML). Currently, the treatment of MDS is still unsatisfactory, although demethylating agents, azacitidine (AZA), and decitabine (Dec) have been successfully used to treat MDS and improve survival rates. However, hematopoietic stem cell transplantation (HSCT) remains the only curative treatment for MDS patients, effectively increasing patient survival and quality of life. Nevertheless, treatment-related toxicity, graft-versus-host disease, infectious complications, and relapse are still major post-transplant issues. In this review, through a retrospective analysis of past and present HSCT for the treatment of MDS, we provide insights for the future.

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造血干细胞移植治疗骨髓增生异常综合征：回顾、现状与未来。

骨髓增生异常综合征（MDS）是一种影响造血干细胞（HSC）的克隆性疾病，主要发生在老年人群中。低危骨髓增生异常综合征的特点是血细胞减少，而高危骨髓增生异常综合征则与转化为急性髓性白血病（AML）的风险增加有关。目前，虽然去甲基化药物、阿扎胞苷（AZA）和地西他滨（Dec）已成功用于治疗 MDS 并提高了存活率，但 MDS 的治疗效果仍不理想。然而，造血干细胞移植（HSCT）仍是治疗MDS患者的唯一治愈方法，可有效提高患者的生存率和生活质量。然而，治疗相关毒性、移植物抗宿主疾病、感染并发症和复发仍是移植后的主要问题。在这篇综述中，我们通过对过去和现在造血干细胞移植治疗 MDS 的回顾性分析，为未来提供了启示。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Transplantation 生物-细胞与组织工程

CiteScore

6.00

自引率

3.00%

发文量

审稿时长

6 months

期刊介绍： Cell Transplantation, The Regenerative Medicine Journal is an open access, peer reviewed journal that is published 12 times annually. Cell Transplantation is a multi-disciplinary forum for publication of articles on cell transplantation and its applications to human diseases. Articles focus on a myriad of topics including the physiological, medical, pre-clinical, tissue engineering, stem cell, and device-oriented aspects of the nervous, endocrine, cardiovascular, and endothelial systems, as well as genetically engineered cells. Cell Transplantation also reports on relevant technological advances, clinical studies, and regulatory considerations related to the implantation of cells into the body in order to provide complete coverage of the field.