The Road More or Less Traveled- Examining the Role of Consolidative Allogeneic Hematopoietic Stem Cell Transplantation After Chimeric Antigen Receptor T Cell Therapy in B-cell ALL
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引用次数: 0
Abstract
Treatment with CD19-targeted chimeric antigen receptor T cell therapy (CD19-CART) has improved salvage rates in children and adults with relapsed and/or refractory B-cell acute lymphoblastic leukemia (ALL). However, not all patients treated with CD19-CAR T cells achieve long-term remission. The role of allogeneic hematopoietic stem cell transplantation as consolidative therapy remains undefined. We aim to review the current literature published to date regarding prognostic markers indicating durable ALL response to CD19-CART and risk factors for relapse after CD19-CART to identify patient cohorts who may benefit from consolidative hematopoietic stem cell transplantation.
CD19 靶向嵌合抗原受体 T 细胞疗法（CD19-CART）提高了复发和/或难治性 B 细胞急性淋巴细胞白血病（ALL）儿童和成人患者的救治率。然而，并非所有接受 CD19-CAR T 细胞治疗的患者都能获得长期缓解。异基因造血干细胞移植作为巩固治疗的作用仍未确定。我们旨在回顾迄今为止发表的有关CD19-CART持久ALL反应预后标志物和CD19-CART后复发风险因素的文献，以确定哪些患者群体可从巩固性造血干细胞移植中获益。
期刊介绍：
Seminars in Hematology aims to present subjects of current importance in clinical hematology, including related areas of oncology, hematopathology, and blood banking. The journal''s unique issue structure allows for a multi-faceted overview of a single topic via a curated selection of review articles, while also offering a variety of articles that present dynamic and front-line material immediately influencing the field. Seminars in Hematology is devoted to making the important and current work accessible, comprehensible, and valuable to the practicing physician, young investigator, clinical practitioners, and internists/paediatricians with strong interests in blood diseases. Seminars in Hematology publishes original research, reviews, short communications and mini- reviews.
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