Clinicopathological characteristics of SMAD4 gene expressions in colorectal cancer patients.

IF 1.5 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Cellular and molecular biology Pub Date : 2024-10-08 DOI:10.14715/cmb/2024.70.9.24

Neda Mansouri, Zahra Mozooni, Mehrdad Haghighi, Shahrzad Soleimani, Rezvan Ghadyani, Ehsan Parsazad, Sepideh Azari, Mostafa Rezaei Tavirani, Sepehr Kahrizi, Ehsan Rouhollahpour Ahangar, Abolfazl Movafagh

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Abstract

Colorectal cancer (CRC) ranks as the third leading cause of cancer-related deaths globally. SMAD4 gene acts as the central mediator of the signaling pathway for transforming growth factor-β (TGFβ) with a significant effect on colorectal cancer. Previous research has confirmed a relationship between the presence of the SMAD4 gene and the survival and progression of colorectal cancer in patients. In this study, our goal was to analyze the presence of SMAD4 in both colorectal cancer and nearby normal tissues. The expression levels of SMAD4 were evaluated in 45 colorectal tumor tissues and 45 adjacent control tissues using the Quantitative Real-Time PCR (qRT-PCR) method. Additionally, we assessed the diagnostic effectiveness of SMAD4 by creating a receiver operating characteristic (ROC) curve. Our findings showed that the expression of SMAD4 was significantly reduced in colorectal cancer patients compared to the adjacent control group sample. Examination of clinicopathological characteristics of patients revealed varied correlations between SMAD4 gene expressions and TMN stage (p<0.0001). These findings suggest that SMAD4 levels could be used as possible diagnostic indicators for colorectal cancer.

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结直肠癌患者 SMAD4 基因表达的临床病理特征

结直肠癌（CRC）是全球癌症相关死亡的第三大原因。SMAD4 基因是转化生长因子-β（TGFβ）信号通路的核心介质，对结直肠癌有显著影响。以往的研究已经证实，SMAD4 基因的存在与结直肠癌患者的生存和病情发展之间存在关系。在本研究中，我们的目标是分析 SMAD4 在结直肠癌和附近正常组织中的存在情况。我们使用定量实时 PCR（qRT-PCR）方法评估了 45 个结直肠肿瘤组织和 45 个邻近对照组织中 SMAD4 的表达水平。此外，我们还通过创建接收者操作特征曲线（ROC）评估了 SMAD4 的诊断效果。我们的研究结果表明，与邻近的对照组样本相比，结直肠癌患者体内 SMAD4 的表达明显减少。对患者临床病理特征的研究显示，SMAD4 基因表达与 TMN 分期之间存在不同的相关性（p

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来源期刊

Cellular and molecular biology 生物-生化与分子生物学

CiteScore

1.60

自引率

12.50%

发文量

331

期刊介绍： Cellular and Molecular Biology publishes original articles, reviews, short communications, methods, meta-analysis notes, letters to editor and comments in the interdisciplinary science of Cellular and Molecular Biology linking and integrating molecular biology, biophysics, biochemistry, enzymology, physiology and biotechnology in a dynamic cell and tissue biology environment, applied to human, animals, plants tissues as well to microbial and viral cells. The journal Cellular and Molecular Biology is therefore open to intense interdisciplinary exchanges in medical, dental, veterinary, pharmacological, botanical and biological researches for the demonstration of these multiple links.