Implementing differentially pigmented skin models for predicting drug response variability across human ancestries.

IF 3.8 3区 医学 Q2 GENETICS & HEREDITY Human Genomics Pub Date : 2024-10-09 DOI:10.1186/s40246-024-00677-7
Sophie Zaaijer, Simon C Groen
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Abstract

Persistent racial disparities in health outcomes have catalyzed legislative reforms and heightened scientific focus recently. However, despite the well-documented properties of skin pigments in binding drug compounds, their impact on therapeutic efficacy and adverse drug responses remains insufficiently explored. This perspective examines the intricate relationships between variation in melanin-based skin pigmentation and pharmacokinetics and -dynamics, highlighting the need for considering diversity in skin pigmentation as a variable to advance the equitability of pharmacological interventions. The article provides guidelines on the selection of New Approach Methods (NAMs) to foster inclusive study designs in preclinical drug development pipelines, leading to an improved level of translatability to the clinic.

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实施不同色素皮肤模型,预测不同人类祖先对药物反应的差异。
在健康结果方面持续存在的种族差异催生了立法改革,并在最近引起了科学界的高度关注。然而,尽管皮肤色素在结合药物化合物方面的特性已得到充分证明,但它们对疗效和药物不良反应的影响仍未得到充分探讨。本文探讨了以黑色素为基础的皮肤色素变化与药代动力学和动力学之间错综复杂的关系,强调有必要将皮肤色素的多样性作为一个变量来考虑,以促进药物干预的公平性。文章提供了选择新方法(NAM)的指南,以促进临床前药物开发流程中的包容性研究设计,从而提高临床转化水平。
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来源期刊
Human Genomics
Human Genomics GENETICS & HEREDITY-
CiteScore
6.00
自引率
2.20%
发文量
55
审稿时长
11 weeks
期刊介绍: Human Genomics is a peer-reviewed, open access, online journal that focuses on the application of genomic analysis in all aspects of human health and disease, as well as genomic analysis of drug efficacy and safety, and comparative genomics. Topics covered by the journal include, but are not limited to: pharmacogenomics, genome-wide association studies, genome-wide sequencing, exome sequencing, next-generation deep-sequencing, functional genomics, epigenomics, translational genomics, expression profiling, proteomics, bioinformatics, animal models, statistical genetics, genetic epidemiology, human population genetics and comparative genomics.
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