The Role of Advanced Glycation End Products in Saphenous Vein Graft Failure.

IF 2.9 3区医学 Q1 MEDICINE, GENERAL & INTERNAL Medical Principles and Practice Pub Date : 2024-10-09 DOI:10.1159/000541879

Alkame Akgümüş, Bedrettin Boyraz, Ahmet Balun

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Abstract

Objective: We aimed to investigate the relationship between advanced glycation end product (AGE) levels in patients with saphenous vein graft (SVG) failure and in patients without SVG failure.

Subjects and methods: In our study, 55 patients with a history of previous coronary artery bypass grafting (CABG) surgery, who subsequently underwent coronary angiography for any reason and were found to have either SVG occlusion or significant lesions, were included as study patients. Additionally, 55 patients who have had CABG surgery without SVG failure for at least 1 year served as the control group. AGE values of the patients were measured using the skin autofluorescence method.

Results: In our study results, we observed a significant difference in AGE levels between the two groups of patients with similar demographic characteristics (SVG failure groups AGE 3.2 [2.8-3.6] vs. control groups AGE 2.4 [2.1-2.7] p < 0.001). In the receiver operating characteristic curve analysis, we determined the ability of AGE levels to detect SVG failure with an area under the curve of 0.869. We found that in patients with AGE >3, it could detect SVG failure with a sensitivity of 70.9% and a specificity of 87.3%.

Conclusions: Our results demonstrate that AGE levels can predict SVG failure risk inexpensively, easily, and quickly.

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高级糖化终产物在无隐静脉移植失败中的作用。

目的我们的目的是研究隐静脉移植术（SVG）失败患者和无SVG失败患者体内高级糖化终末产物（AGE）水平之间的关系：在我们的研究中，55 名既往接受过冠状动脉旁路移植术（CABG）手术的患者作为研究对象，这些患者随后因各种原因接受了冠状动脉造影术，并发现 SVG 闭塞或存在明显病变。此外，55 名接受过 CABG 手术且 SVG 至少失效 1 年的患者作为对照组。采用皮肤自动荧光法测量患者的 AGE 值：在研究结果中，我们观察到两组具有相似人口统计学特征的患者之间的 AGE 水平存在显著差异（SVG 失败组 AGE 3.2 (2.8-3.6) vs 对照组 AGE 2.4 (2.1-2.7) p <0.001）。在 ROC 曲线分析中，我们确定了 AGE 水平检测 SVG 衰竭的能力，曲线下面积为 0.869。我们发现，在 AGE >3 患者中，检测 SVG 衰竭的敏感性为 70.9%，特异性为 87.3%：我们的研究结果表明，AGE 水平可以廉价、简便、快速地预测 SVG 功能衰竭的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical Principles and Practice 医学-医学：内科

CiteScore

6.10

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Medical Principles and Practice'', as the journal of the Health Sciences Centre, Kuwait University, aims to be a publication of international repute that will be a medium for dissemination and exchange of scientific knowledge in the health sciences.