Desmoplastic Fibroma of the Gnathic Bones-A Systematic Review.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Oral diseases Pub Date : 2024-10-07 DOI:10.1111/odi.15153

Felippe José Almeida Loureiro, Wictor Rodrigues Nogueira, Mateus José Dutra, Grazielle Oliveira Stelter, Lauren Frenzel Schuch, Felipe Martins Silveira, Vivian Petersen Wagner, Manoela Domingues Martins, Marco Antônio Trevizani Martins

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Abstract

Objective: To summarize published information about the desmoplastic fibroma of the gnathic bones into a descriptive analysis of the main features of this condition.

Material and methods: A systematic review according to the PRISMA guidelines was conducted. Electronic search was performed in four databases and in the gray literature. Case reports and case series were included. Frequencies were obtained for descriptive analysis.

Results: We identified 66 articles, for a total of 96 cases. Female patients (55.8%) in the first decade of life (40.6%) with a mean age of 18.2 years were more affected. The mandible was the most affected bone with 81.2% of the cases. The main clinical feature was painless swelling (54.2%). Most of the imaging examinations (radiological, computed tomography, and magnetic resonance) showed well-defined radiolucencies (65.4%) lesions. The treatment was surgical removal in all cases. The recurrence rate was 10.8% and all in the posterior mandible. Spindle cell fibroblasts in a collagenized stroma were often described in the histopathological features. Vimentin, smooth muscle actin, and β-catenin were common immunohistochemical markers.

Conclusion: Desmoplastic fibroma is a locally aggressive lesion that commonly affects the jaws in children. Histopathology is essential for diagnosis, and the pathogenesis of this tumor should be further investigated.

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龈骨脱落性纤维瘤--系统综述

摘要总结已发表的有关胫骨脱鳞纤维瘤的信息，对该病的主要特征进行描述性分析：根据 PRISMA 指南进行了系统性综述。在四个数据库和灰色文献中进行了电子检索。纳入了病例报告和系列病例。结果：我们共发现了 66 篇文章，总计 1,000 个病例：我们确定了 66 篇文章，共计 96 个病例。女性患者（55.8%）多发于出生后的前十年（40.6%），平均年龄为 18.2 岁。下颌骨是受影响最大的骨骼，占病例总数的 81.2%。主要临床特征是无痛性肿胀（54.2%）。大多数影像学检查（放射学、计算机断层扫描和磁共振）显示病变部位有清晰的放射线（65.4%）。所有病例均采用手术切除治疗。复发率为10.8%，且均位于下颌骨后方。组织病理学特征通常描述了胶原基质中的纺锤形成纤维细胞。波形蛋白、平滑肌肌动蛋白和β-catenin是常见的免疫组化标记物：结论：脱屑性纤维瘤是一种常见于儿童颌骨的局部侵袭性病变。结论：脱瘤性纤维瘤是一种常见于儿童颌骨的局部侵袭性病变，组织病理学检查对诊断至关重要，应进一步研究该肿瘤的发病机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.