Cytoplasmic mtDNA clearance suppresses inflammatory immune responses.

IF 13 1区 生物学 Q1 CELL BIOLOGY Trends in Cell Biology Pub Date : 2024-11-01 Epub Date: 2024-10-07 DOI:10.1016/j.tcb.2024.09.002
Chenghao Yan, Xu Liu, Haodong Xu, Liming Wang
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引用次数: 0

Abstract

Upon various stresses, mtDNA leaks from mitochondria into the cytoplasm, leading to cellular dysfunction and inflammation, thereby exacerbating disease progression. The autophagy-lysosome pathway has emerged as a pivotal quality control mechanism for eliminating abnormal cytoplasmic mtDNA. This article summarizes the mechanisms underlying mtDNA-triggered inflammation and how cytoplasmic mtDNA is eliminated.

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细胞质 mtDNA 清除抑制炎症免疫反应。
在各种压力下,mtDNA 会从线粒体泄漏到细胞质中,导致细胞功能障碍和炎症,从而加剧疾病的发展。自噬-溶酶体途径已成为消除异常胞质 mtDNA 的关键质量控制机制。本文总结了mtDNA引发炎症的机制以及如何消除细胞质mtDNA。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Trends in Cell Biology
Trends in Cell Biology 生物-细胞生物学
CiteScore
32.00
自引率
0.50%
发文量
160
审稿时长
61 days
期刊介绍: Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.
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