Small non-coding RNAs as diagnostic, prognostic and predictive biomarkers of gynecological cancers: an update.

IF 3.9 3区 医学 Q1 PATHOLOGY Expert Review of Molecular Diagnostics Pub Date : 2024-10-10 DOI:10.1080/14737159.2024.2408740
Marios A Diamantopoulos, Panagiotis G Adamopoulos, Andreas Scorilas
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Abstract

Introduction: Non-coding RNAs (ncRNAs) comprise a heterogeneous cluster of RNA molecules. Emerging evidence suggests their involvement in various aspects of tumorigenesis, particularly in gynecological malignancies. Notably, ncRNAs have been implicated as mediators within tumor signaling pathways, exerting their influence through interactions with RNA or proteins. These findings further highlight the hypothesis that ncRNAs constitute therapeutic targets and point out their clinical potential as stratification biomarkers.

Areas covered: The review outlines the use of small ncRNAs, including miRNAs, tRNA-derived small RNAs, PIWI-interacting RNAs and circular RNAs, for diagnostic, prognostic, and predictive purposes in gynecological cancers. It aims to increase our knowledge of their functions in tumor biology and their translation into clinical practice.

Expert opinion: By leveraging interdisciplinary collaborations, scientists can decipher the riddle of small ncRNA biomarkers as diagnostic, prognostic and predictive biomarkers of gynecological tumors. Integrating small ncRNA-based assays into clinical practice will allow clinicians to provide cure plans for each patient, reducing the likelihood of adverse responses. Nevertheless, addressing challenges such as standardizing experimental methodologies and refining diagnostic assays is imperative for advancing small ncRNA research in gynecological cancer.

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作为妇科癌症诊断、预后和预测生物标志物的小非编码 RNA:最新进展。
导言非编码 RNA(ncRNA)是一组异构的 RNA 分子。新的证据表明,它们参与了肿瘤发生的各个方面,尤其是妇科恶性肿瘤。值得注意的是,ncRNA 被认为是肿瘤信号通路中的介质,通过与 RNA 或蛋白质的相互作用施加影响。这些发现进一步突出了 ncRNA 构成治疗靶点的假设,并指出了它们作为分层生物标志物的临床潜力:综述概述了小ncRNAs(包括miRNAs、tRNA衍生的小RNAs、PIWI相互作用RNAs和环状RNAs)在妇科癌症诊断、预后和预测中的应用。其目的是增加我们对这些RNA在肿瘤生物学中的功能的了解,并将其转化为临床实践:通过跨学科合作,科学家们可以破解小ncRNA生物标志物作为妇科肿瘤诊断、预后和预测生物标志物的谜团。将基于小 ncRNA 的检测方法纳入临床实践,将使临床医生能够为每位患者提供治疗方案,降低不良反应发生的可能性。然而,要推进妇科癌症的小 ncRNA 研究,就必须应对各种挑战,如实验方法的标准化和诊断测定的完善。
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来源期刊
CiteScore
6.60
自引率
0.00%
发文量
71
审稿时长
1 months
期刊介绍: Expert Review of Molecular Diagnostics (ISSN 1473-7159) publishes expert reviews of the latest advancements in the field of molecular diagnostics including the detection and monitoring of the molecular causes of disease that are being translated into groundbreaking diagnostic and prognostic technologies to be used in the clinical diagnostic setting. Each issue of Expert Review of Molecular Diagnostics contains leading reviews on current and emerging topics relating to molecular diagnostics, subject to a rigorous peer review process; editorials discussing contentious issues in the field; diagnostic profiles featuring independent, expert evaluations of diagnostic tests; meeting reports of recent molecular diagnostics conferences and key paper evaluations featuring assessments of significant, recently published articles from specialists in molecular diagnostic therapy. Expert Review of Molecular Diagnostics provides the forum for reporting the critical advances being made in this ever-expanding field, as well as the major challenges ahead in their clinical implementation. The journal delivers this information in concise, at-a-glance article formats: invaluable to a time-constrained community.
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