Relative Tumour Volume in Canine Oral Melanoma Staging and Prognosis.

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES Veterinary and comparative oncology Pub Date : 2024-12-01 Epub Date: 2024-10-10 DOI:10.1111/vco.13018
Marta L Silva, Inês Martinho, Margarida Rocha, Marina Martano, Kevin P Spindler, Paolo Buracco, Davide Giacobino, Helena F Florindo, Lisa A Mestrinho
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Abstract

Melanoma is one of the most common canine oral malignant tumours and is highly aggressive and metastatic, even at the early stages of development. Surgery relies on wide excision of the primary tumour and regional lymphadenectomy, with or without adjuvant therapy. Tumour location and size are important when considering staging, which ultimately affects the curative intent of surgery. Nevertheless, absolute tumour volume (TV) is not related to the vast phenotypic variability within canine breeds. This study aimed to determine the cutoff values of two ratios-tumour-to-head volume (THR) and tumour-to-body volume (TBR)-and assess whether they could be associated with the odds of finding metastasis at presentation and/or the likelihood of achieving tumour-free excision margins. A retrospective case series involving 51 dogs was used to evaluate the preoperative head/neck and chest computed tomography and histopathology of the primary mass and excised lymph nodes. Higher TV, THR% and TBR% values were associated with bone lysis and mitotic count (MC). The Ki67 index was significantly associated with local and distant metastases at presentation, whereas MC was associated with local metastasis alone. Tumour-infiltrated surgical margins were associated with caudally located tumours, regardless of the tumour size. Dogs with lymph node metastasis at presentation were seven times more prone to have local relapse. TV, THR% and TBR% values were positively associated with local lymph node metastasis at presentation. Cutoff values for both TV and TBR% were proposed to predict lymph node metastasis at presentation (TV = 6.423 cm3 and TBR% = 0.043), being supported by post-surgical survival analysis.

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犬口腔黑色素瘤分期和预后中的相对肿瘤体积
黑色素瘤是最常见的犬口腔恶性肿瘤之一,具有高度侵袭性和转移性,即使在发病初期也是如此。手术主要依靠广泛切除原发肿瘤和区域淋巴结切除术,并采用或不采用辅助治疗。在考虑分期时,肿瘤的位置和大小非常重要,这最终会影响手术的治愈意图。然而,肿瘤的绝对体积(TV)与犬种的巨大表型差异无关。本研究旨在确定肿瘤与头部体积(THR)和肿瘤与身体体积(TBR)这两个比率的临界值,并评估它们是否与发病时发现转移的几率和/或达到无肿瘤切除边缘的可能性有关。该研究采用了一项涉及 51 只狗的回顾性病例系列,对术前头颈部和胸部计算机断层扫描以及原发肿块和切除淋巴结的组织病理学进行了评估。较高的TV、THR%和TBR%值与骨溶解和有丝分裂计数(MC)相关。Ki67 指数与发病时的局部转移和远处转移密切相关,而 MC 仅与局部转移有关。无论肿瘤大小如何,肿瘤浸润的手术边缘都与尾部肿瘤有关。出现淋巴结转移的犬局部复发的几率是其他犬的七倍。TV、THR%和TBR%值与发病时的局部淋巴结转移呈正相关。我们提出了TV和TBR%的临界值(TV = 6.423 cm3和TBR% = 0.043)来预测发病时的淋巴结转移,并得到了手术后生存分析的支持。
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来源期刊
Veterinary and comparative oncology
Veterinary and comparative oncology 农林科学-兽医学
CiteScore
4.80
自引率
9.50%
发文量
75
审稿时长
>24 weeks
期刊介绍: Veterinary and Comparative Oncology (VCO) is an international, peer-reviewed journal integrating clinical and scientific information from a variety of related disciplines and from worldwide sources for all veterinary oncologists and cancer researchers concerned with aetiology, diagnosis and clinical course of cancer in domestic animals and its prevention. With the ultimate aim of diminishing suffering from cancer, the journal supports the transfer of knowledge in all aspects of veterinary oncology, from the application of new laboratory technology to cancer prevention, early detection, diagnosis and therapy. In addition to original articles, the journal publishes solicited editorials, review articles, commentary, correspondence and abstracts from the published literature. Accordingly, studies describing laboratory work performed exclusively in purpose-bred domestic animals (e.g. dogs, cats, horses) will not be considered.
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