Impact of Neurostimulation, Immunomodulation, Topical Medication Application, and Surgical Reconstruction on Corneal Nerve Function and Regeneration.

IF 2 4区医学 Q2 OPHTHALMOLOGY Eye & Contact Lens-Science and Clinical Practice Pub Date : 2024-10-11 DOI:10.1097/ICL.0000000000001130

Taylor N Drake, John D Sheppard

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Abstract

Abstract: The corneal epithelium, supplied by thousands of nerve endings, plays a substantial role in absorbing and distributing nutrients along the ocular surface. Many studies have explored the influence of various modalities in regulating tear production to manage corneal disorders and dry eye disease. These findings have highlighted the advantages of enhancing corneal nerve function and regeneration through neurostimulation, neural signaling, immunomodulation, topical medication application, and surgical reconstruction. The purpose of this narrative review article was to provide an overview of the current state of knowledge on this topic based on a PubMed database literature search for relevant animal and human studies investigating the modification of the trigeminal pathway to restore corneal nerve function and improve overall ocular health. Further investigation into this area of research is important to help guide new therapeutic targets for the prevention and development of treatments of corneal degeneration.

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神经刺激、免疫调节、局部用药和手术重建对角膜神经功能和再生的影响。

摘要：角膜上皮有数千个神经末梢，在吸收和分配眼表营养物质方面发挥着重要作用。许多研究都探讨了各种调节泪液分泌的方法对控制角膜疾病和干眼症的影响。这些研究结果凸显了通过神经刺激、神经信号传导、免疫调节、局部用药和手术重建来增强角膜神经功能和角膜神经再生的优势。这篇叙述性综述文章的目的是根据 PubMed 数据库的文献检索，概述目前关于这一主题的知识状况，这些文献检索涉及相关的动物和人体研究，这些研究调查了改变三叉神经通路以恢复角膜神经功能和改善整体眼部健康的情况。对这一研究领域的进一步调查非常重要，有助于为预防和开发治疗角膜变性的新治疗目标提供指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Eye & Contact Lens-Science and Clinical Practice OPHTHALMOLOGY-

CiteScore

4.50

自引率

4.30%

发文量

150

审稿时长

6-12 weeks

期刊介绍： Eye & Contact Lens: Science and Clinical Practice is the official journal of the Contact Lens Association of Ophthalmologists (CLAO), an international educational association for anterior segment research and clinical practice of interest to ophthalmologists, optometrists, and other vision care providers and researchers. Focusing especially on contact lenses, it also covers dry eye disease, MGD, infections, toxicity of drops and contact lens care solutions, topography, cornea surgery and post-operative care, optics, refractive surgery and corneal stability (eg, UV cross-linking). Peer-reviewed and published six times annually, it is a highly respected scientific journal in its field.