Epigenetic regulation of Epstein–Barr virus: From bench to bedside

Clinical and translational discovery Pub Date : 2024-09-30 DOI:10.1002/ctd2.357

Xiao Gao, Hao-Xu Yang, Shu Cheng, Hua-Man Cai, Jie Xiong, Wei-Li Zhao

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Abstract

Background

Epstein–Barr virus (EBV) is a double-stranded DNA herpesvirus and establishes life-long infection in 95% of the world's populations.

Main body

EBV is critically involved in multiple diseases. Aberrant signaling pathways, immune escape, and metabolic reprogramming play essential roles in EBV-mediated pathogenesis. However, the underlying mechanisms have not yet been fully elucidated. Here we reviewed recent advances on the epigenetic regulation of EBV pathogenesis, which may translate to potential therapeutic strategies in EBV-associated diseases.

Conclusion

Growing evidence has suggested that viral infections reconstruct epigenome to modulate gene expression both in the host and the virus levels.

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Epstein-Barr 病毒的表观遗传调控：从工作台到床边

背景爱泼斯坦-巴氏病毒（EBV）是一种双链 DNA 疱疹病毒，在全球 95% 的人群中可终身感染。 EBV 主体与多种疾病密切相关。信号通路异常、免疫逃逸和代谢重编程在 EBV 介导的发病机制中发挥着至关重要的作用。然而，其潜在机制尚未完全阐明。在此，我们回顾了有关 EBV 发病的表观遗传调控的最新进展，这些进展可能会转化为 EBV 相关疾病的潜在治疗策略。结论越来越多的证据表明，病毒感染会重构表观基因组，从而调节宿主和病毒水平的基因表达。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and translational discovery

CiteScore

1.00

自引率

0.00%

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