Preservation of Hypotensive Activity in Freeze-Dried Drugs of Dinitrozyl Iron Complexes with Glutathione (Oxacom) Stored for 15 Years at Room Temperature

Abstract

Complete preservation of the antihypertensive activity of the freeze-dried drug Oxacom has been demonstrated after storing it for 15 years at room temperature in vessels with the air pumped out; this is due to the presence of a binuclear form of a dinitrosyl iron complex with glutathione in this drug. It was proposed that the oxidation of glutathione ligands in the composition of dinitrosyl iron complexes by air gradually penetrating into the vessels, which could lead to the decomposition of these complexes, was prevented by a significant amount of free (not included in dinitrosyl iron complexes) glutathione in this drug.