Front Cover: Synthetic Strategies to Prepare Bioactive Lysine and Peptide Conjugates With Triazolium Derivatives (Eur. J. Org. Chem. 38/2024)

Abstract

The Front Cover shows a set of Safirinium-dye derivatives used for the facile preparation of peptide conjugates as potential elastase inhibitors, by exploiting a lysine side chain as an effective linker between the dye and the peptide. With an optimized peptide sequence forming the core and triazolium derivatives acting as particular caps, we can create molecular tools capable of tuning the activity of a selected enzyme. Details of this approach are reported in the Research Article by R. Latajka, A. M. Papini and co-workers (DOI: 10.1002/ejoc.202400399). Structure taken from PDB ID: 1QR3.