A novel neuronal circuit: Tanycytes mediate defensive metabolic responses following acute high-temperature exposure

Brain-X Pub Date : 2024-10-08 DOI:10.1002/brx2.70003
Qi Chen, Anke Brüning-Richardson, Ruoli Chen, Shuang Zou, Yu-Long Lan
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Abstract

A schematic diagram of a proposed neural circuit for high temperature-induced feeding inhibition. Acute high temperature exposure activates excitatory neurons in the parabrachial nucleus brain area, promotes the release of vascular endothelial growth factor A from tanycytes, and acts on agouti-related protein neurons in the ARC brain area to inhibit feeding behavior.

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新型神经元回路:澹细胞介导急性高温暴露后的防御性代谢反应
高温诱导摄食抑制的神经回路示意图。急性高温暴露会激活胫旁核脑区的兴奋性神经元,促进澹细胞释放血管内皮生长因子 A,并作用于 ARC 脑区的激动相关蛋白神经元,从而抑制摄食行为。
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