Mixed autoimmune hemolytic anemia as the initial presentation of systemic lupus erythematosus: A case report and review

EJHaem Pub Date : 2024-09-11 DOI:10.1002/jha2.1008
Brian P. Edwards, Sidhartha Gautam Senapati, Mariia Kasianchyk, Joel Shah, Fatih Ayvali, Satish Maharaj
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Abstract

Autoimmune hemolytic anemia (AIHA) is an acquired condition caused by autoantibody mediated destruction of erythrocytes. AIHA is classified as warm or cold depending on whether the autoantibodies involved react optimally at or below body temperature (37°C), respectively. Mixed AIHA, with features of both, is rare and clinically more severe. We report a case of mixed AIHA that was found to be the presentation of systemic lupus erythematosus (SLE). Treatment with rituximab and prednisone resulted in good response. Although more commonly associated with warm AIHA, SLE can present with mixed AIHA.

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混合性自身免疫性溶血性贫血是系统性红斑狼疮的最初表现:病例报告与综述
自身免疫性溶血性贫血(AIHA)是由自身抗体介导的红细胞破坏引起的后天性疾病。根据所涉及的自身抗体是在体温(37°C)下还是在体温以下产生最佳反应,AIHA 可分为温性和冷性两种。混合型 AIHA 具有两者的特征,但较为罕见,临床症状也更为严重。我们报告了一例混合型 AIHA,发现它是系统性红斑狼疮(SLE)的一种表现形式。使用利妥昔单抗和泼尼松治疗后,患者反应良好。虽然系统性红斑狼疮更常见于温热型AIHA,但它也可能表现为混合型AIHA。
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