Marta Grau, Melina Pol, Anna Montaner, Pablo Mozas, Ferran Nadeu, Ian Márquez-López, Jose Ramon Álamo, Alba Navarro, Daniel Martinez, Gerard Frigola, Olga Balagué, Mónica Lopez-Guerra, Dolors Colomer, Silvia Ruiz-Gaspà, Melika Bashiri, Juan Correa, Eva Giné, Armando López-Guillermo, Elias Campo, Cristina López, Estella Matutes, Sílvia Beà
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Abstract
The genetic landscape underlying the transformation of splenic diffuse red pulp small B-cell lymphoma (SDRPL) is not well understood. The present study aimed to unravel the genomic alterations involved in the progression and transformation of SDRPL. We performed genetic studies on both SDRPL and subsequent or synchronous diffuse large B cell lymphoma (DLBCL) samples in three SDRPL patients who eventually developed DLBCL. Our findings revealed that SDRPL cases progressing to DLBCL acquired genomic alterations in genes related to the cell cycle (CDKN2A/B, TP53, MYC and CCND3) and B cell development (BCL6).
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