Junhao Ruan, Xi Cao, Yipeng Zhou, Xiaoyu Yang, Weijie Chen
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引用次数: 0
Abstract
Six-membered endocyclic benzyl/allyl enecarbamates undergo a Pd-catalyzed decarboxylation process to generate endocyclic 1-azaallyl anions and Pd–benzyl/allyl cations. The ion pair then react with each other followed by reduction to ultimately give unprotected -2-(hetero)aryl-3-benzylpiperidines and 2-(hetero)aryl-3-allylpiperidines in 31−91% yields as single cis-diastereomers. These reactions represent a strategy to form unprotected β-substituted piperidines, which generates elusive endocyclic 1-azaallyl anion intermediates by introducing the negative charge from the N-terminal.
期刊介绍：
Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry.
The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.
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