{"title":"Metabolic–epigenetic rewiring in CD8+ T cells via lactate-dependent histone lactylation","authors":"Renqiang Sun, Hongbo Chi","doi":"10.1038/s41590-024-01991-x","DOIUrl":null,"url":null,"abstract":"The interplay of metabolites with epigenetic programs influences CD8+ T cell fate decisions. Here, Raychaudhuri et al. show that lactate-dependent histone lactylation tunes CD8+ T cell metabolism and function by regulating epigenetic and transcriptional remodeling.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"25 11","pages":"1980-1982"},"PeriodicalIF":27.7000,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Immunology","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41590-024-01991-x","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The interplay of metabolites with epigenetic programs influences CD8+ T cell fate decisions. Here, Raychaudhuri et al. show that lactate-dependent histone lactylation tunes CD8+ T cell metabolism and function by regulating epigenetic and transcriptional remodeling.
期刊介绍：
Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.
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