Consumption of aspartame and risk of breast cancer in the Nurses’ Health Studies

Andrea Romanos-Nanclares, Eva Schernhammer, Walter C Willett, Michelle D Holmes, Wendy Y Chen, A Heather Eliassen
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Abstract

Debate persists regarding the potential carcinogenicity of aspartame as suggested by experimental studies. Therefore, we prospectively evaluated whether aspartame consumption is associated with breast cancer risk in the Nurses’ Health Study (NHS) and Nurses’ Health study II (NHSII). We used Cox models to calculate HRs and 95% CIs. During up to 30 years of follow-up with 4-yearly assessments of intake, we documented 10,814 invasive breast cancer cases. Overall, there was no association between aspartame consumption and invasive breast cancer risk (HR per 200 mg/day [approximately one 12 oz serving of diet soda] = 1.00 (95% CI 0.98, 1.03). We observed similar lack of associations after excluding cases occurring in the first 10 years of follow-up (n = 3,125) (HR per 200 mg/day 1.00, 95% CI 0.97, 1.03). In these cohorts, aspartame consumption did not increase breast cancer risk.
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护士健康研究中的阿斯巴甜食用量与乳腺癌风险
实验研究表明阿斯巴甜具有潜在致癌性,但这一问题一直存在争议。因此,我们在 "护士健康研究"(NHS)和 "护士健康研究II"(NHSII)中对食用阿斯巴甜是否与乳腺癌风险相关进行了前瞻性评估。我们使用 Cox 模型计算 HRs 和 95% CIs。在长达 30 年的随访过程中,我们每 4 年对摄入量进行一次评估,共记录了 10,814 例浸润性乳腺癌病例。总体而言,阿斯巴甜的摄入量与浸润性乳腺癌风险之间没有关联(每 200 毫克/天[约一份 12 盎司的健怡苏打水]的 HR = 1.00 (95% CI 0.98, 1.03))。在排除前 10 年的随访病例(n = 3,125)后,我们也观察到了类似的不相关性(每 200 毫克/天的 HR 为 1.00,95% CI 为 0.97,1.03)。在这些队列中,食用阿斯巴甜不会增加乳腺癌风险。
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