Hirotaka Murase , Mio Eto , Jeongsu Lee , Yosuke Taniguchi , Shuhei Imoto , Shigeki Sasaki
{"title":"Site-specific acetyl modification of 2′-OH of RNA by an oligonucleotide acetylating reagent†","authors":"Hirotaka Murase , Mio Eto , Jeongsu Lee , Yosuke Taniguchi , Shuhei Imoto , Shigeki Sasaki","doi":"10.1039/d4cc04672b","DOIUrl":null,"url":null,"abstract":"<div><div>The method for a site-specific RNA acetylation using a novel oligonucleotide acetylating probe (Ac-probe) has been developed. It was confirmed that the acetyl group was site-specifically introduced to a 2′-OH of the sugar part of the target RNA <em>via</em> the formation of the RNA-probe duplex.</div></div>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"60 91","pages":"Pages 13440-13442"},"PeriodicalIF":4.2000,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Communications","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1359734524022171","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/22 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
The method for a site-specific RNA acetylation using a novel oligonucleotide acetylating probe (Ac-probe) has been developed. It was confirmed that the acetyl group was site-specifically introduced to a 2′-OH of the sugar part of the target RNA via the formation of the RNA-probe duplex.
期刊介绍:
ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.