Impaired Gait, Postural Instability, and Rigidity in Relation to CB1 Receptor Availability in Parkinson's Disease.

IF 7.4 1区医学 Q1 CLINICAL NEUROLOGY Movement Disorders Pub Date : 2024-10-22 DOI:10.1002/mds.30042

Riikka Ajalin, Haidar Al-Abdulrasul, Jouni M Tuisku, Jussi Hirvonen, Salla Lahdenpohja, Juha O Rinne, Anna Brück

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Abstract

Background: In Parkinson's disease (PD), postural instability and gait disorder (PIGD) symptoms are associated with a worse prognosis for an unknown reason.

Objective: The objective was to explore the relationship between cannabinoid receptor type 1 (CB1R) availability and motor symptoms in PD with [¹⁸F]FMPEP-d₂ positron emission tomography (PET).

Methods: Fifteen individuals with PD underwent [¹⁸F]FMPEP-d₂ PET to measure cerebral CB1R availability. The Unified Parkinson's Disease Rating Scale motor part (UPDRS-III) was used to evaluate the motor symptoms.

Results: A negative correlation was observed between [¹⁸F]FMPEP-d₂ V_T and PIGD score (P = 0.002) as well as rigidity subscore (P < 0.001). Both clusters covered widespread areas of both hemispheres. In contrast, tremor or bradykinesia did not correlate to [¹⁸F]FMPEP-d₂ V_T.

Conclusions: Gait, postural instability, and rigidity in PD are associated with decreased CB1R availability, unlike tremor or bradykinesia, suggesting that the endocannabinoid system has a role in the pathophysiology of different motor symptoms in PD. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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帕金森病患者步态受损、姿势不稳定和僵硬与 CB1 受体的可用性有关。

背景：在帕金森病（PD）中，姿势不稳和步态障碍（PIGD）症状与预后恶化相关，原因不明：目的：利用[18F]FMPEP-d2正电子发射断层扫描（PET）探讨1型大麻素受体（CB1R）可用性与帕金森病运动症状之间的关系：15名帕金森病患者接受了[18F]FMPEP-d2 PET检查，以测量大脑CB1R的可用性。统一帕金森病评定量表运动部分（UPDRS-III）用于评估运动症状：结果：[18F]FMPEP-d2 VT 与 PIGD 评分（P = 0.002）以及僵直子评分（P 18F]FMPEP-d2 VT）之间呈负相关：结论：与震颤或运动迟缓不同，步态、姿势不稳定性和僵直在帕金森病中与CB1R可用性降低有关，这表明内源性大麻素系统在帕金森病不同运动症状的病理生理学中发挥作用。© 2024 作者简介运动障碍》由 Wiley Periodicals LLC 代表国际帕金森和运动障碍协会出版。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Movement Disorders 医学-临床神经学

CiteScore

13.30

自引率

8.10%

发文量

371

审稿时长

12 months

期刊介绍： Movement Disorders publishes a variety of content types including Reviews, Viewpoints, Full Length Articles, Historical Reports, Brief Reports, and Letters. The journal considers original manuscripts on topics related to the diagnosis, therapeutics, pharmacology, biochemistry, physiology, etiology, genetics, and epidemiology of movement disorders. Appropriate topics include Parkinsonism, Chorea, Tremors, Dystonia, Myoclonus, Tics, Tardive Dyskinesia, Spasticity, and Ataxia.