Time-dependent simulation of blood flow through an abdominal aorta with iliac arteries

IF 2.2 4区 生物学 Q3 BIOPHYSICS European Biophysics Journal Pub Date : 2024-10-18 DOI:10.1007/s00249-024-01724-w
Grzegorz Górski, Krzysztof Kucab
{"title":"Time-dependent simulation of blood flow through an abdominal aorta with iliac arteries","authors":"Grzegorz Górski,&nbsp;Krzysztof Kucab","doi":"10.1007/s00249-024-01724-w","DOIUrl":null,"url":null,"abstract":"<div><p>Atherosclerosis is one of the important diseases of the circulatory system because atherosclerotic plaques cause significant disruption of blood flow. Therefore, it is very important to properly understand these processes and skillfully simulate blood flow. In our work, we consider blood flow through an abdominal aorta with iliac arteries, assuming that the right iliac artery is narrowed by an atherosclerotic lesion. Blood flow is simulated using the laminar, standard <span>\\(k-\\omega\\)</span> and standard <span>\\(k-\\epsilon\\)</span> models. The obtained results show that despite the use of identical initial conditions, the distribution of velocity flow and wall shear stress depends on the choice of flow simulation model. For the <span>\\(k-\\epsilon\\)</span> model, we obtain higher values of speed and wall shear stress on atherosclerotic plaque than in the other two models. The laminar and <span>\\(k-\\omega\\)</span> models predict larger areas where reverse blood flow occurs in the area behind the atherosclerotic lesion. This effect is associated with negative wall shear stress. These two models give very similar results. The results obtained by us, and those reported in the literature, indicate that <span>\\(k-\\omega\\)</span> model is the most suitable for blood flow analysis.</p></div>","PeriodicalId":548,"journal":{"name":"European Biophysics Journal","volume":"53 7-8","pages":"429 - 445"},"PeriodicalIF":2.2000,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00249-024-01724-w.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Biophysics Journal","FirstCategoryId":"2","ListUrlMain":"https://link.springer.com/article/10.1007/s00249-024-01724-w","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOPHYSICS","Score":null,"Total":0}
引用次数: 0

Abstract

Atherosclerosis is one of the important diseases of the circulatory system because atherosclerotic plaques cause significant disruption of blood flow. Therefore, it is very important to properly understand these processes and skillfully simulate blood flow. In our work, we consider blood flow through an abdominal aorta with iliac arteries, assuming that the right iliac artery is narrowed by an atherosclerotic lesion. Blood flow is simulated using the laminar, standard \(k-\omega\) and standard \(k-\epsilon\) models. The obtained results show that despite the use of identical initial conditions, the distribution of velocity flow and wall shear stress depends on the choice of flow simulation model. For the \(k-\epsilon\) model, we obtain higher values of speed and wall shear stress on atherosclerotic plaque than in the other two models. The laminar and \(k-\omega\) models predict larger areas where reverse blood flow occurs in the area behind the atherosclerotic lesion. This effect is associated with negative wall shear stress. These two models give very similar results. The results obtained by us, and those reported in the literature, indicate that \(k-\omega\) model is the most suitable for blood flow analysis.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
随时间变化的腹主动脉与髂动脉血流模拟。
动脉粥样硬化是循环系统的重要疾病之一,因为动脉粥样硬化斑块会严重破坏血流。因此,正确理解这些过程并巧妙地模拟血流非常重要。在我们的工作中,我们考虑了流经腹主动脉和髂动脉的血流,假设右髂动脉因动脉粥样硬化病变而狭窄。使用层流、标准 k - ω 和标准 k - ϵ 模型模拟了血流。结果表明,尽管使用了相同的初始条件,但血流速度和血流壁剪应力的分布取决于血流模拟模型的选择。对于 k - ϵ 模型,我们在动脉粥样硬化斑块上获得了比其他两个模型更高的速度和壁剪应力值。层流模型和 k - ω 模型预测在动脉粥样硬化病变后方的区域会出现较大的反向血流。这种效应与负壁剪应力有关。这两个模型得出的结果非常相似。我们获得的结果和文献报道的结果表明,k - ω 模型最适合用于血流分析。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
European Biophysics Journal
European Biophysics Journal 生物-生物物理
CiteScore
4.30
自引率
0.00%
发文量
43
审稿时长
6-12 weeks
期刊介绍: The journal publishes papers in the field of biophysics, which is defined as the study of biological phenomena by using physical methods and concepts. Original papers, reviews and Biophysics letters are published. The primary goal of this journal is to advance the understanding of biological structure and function by application of the principles of physical science, and by presenting the work in a biophysical context. Papers employing a distinctively biophysical approach at all levels of biological organisation will be considered, as will both experimental and theoretical studies. The criteria for acceptance are scientific content, originality and relevance to biological systems of current interest and importance. Principal areas of interest include: - Structure and dynamics of biological macromolecules - Membrane biophysics and ion channels - Cell biophysics and organisation - Macromolecular assemblies - Biophysical methods and instrumentation - Advanced microscopics - System dynamics.
期刊最新文献
Exploring characteristic features for effective HCN1 channel inhibition using integrated analytical approaches: 3D QSAR, molecular docking, homology modelling, ADME and molecular dynamics Quantitative characterization of non-specific interaction of two globular proteins with Dextran T70 in a binary mixture The origin of mutational epistasis Time-dependent simulation of blood flow through an abdominal aorta with iliac arteries Extreme enthalpy‒entropy compensation in the dimerization of small solutes in aqueous solution
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1