Cognitive effects of brief and intensive neurofeedback treatment in schizophrenia: a single center pilot study.

IF 3.1 Q2 NEUROSCIENCES AIMS Neuroscience Pub Date : 2024-09-09 eCollection Date: 2024-01-01 DOI:10.3934/Neuroscience.2024021
Fabrizio Turiaco, Fiammetta Iannuzzo, Giovanni Genovese, Clara Lombardo, Maria Catena Silvestri, Laura Celebre, Maria Rosaria Anna Muscatello, Antonio Bruno
{"title":"Cognitive effects of brief and intensive neurofeedback treatment in schizophrenia: a single center pilot study.","authors":"Fabrizio Turiaco, Fiammetta Iannuzzo, Giovanni Genovese, Clara Lombardo, Maria Catena Silvestri, Laura Celebre, Maria Rosaria Anna Muscatello, Antonio Bruno","doi":"10.3934/Neuroscience.2024021","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Schizophrenia is characterized by significant cognitive impairments and affects up to 98% of patients. Neurofeedback (NF) offers a means to modulate neural network function through cognitive processes such as learning and memorization, with documented structural changes in the brain, most notably an increase in grey matter volume in targeted regions.</p><p><strong>Methods: </strong>The present 2-week, open-label, preliminary study aims to evaluate the efficacy on cognition of an adjunctive short and intensive (8 daily sessions lasting 30 minutes) alpha/theta NF training in a sample of subjects affected by schizophrenia on stabilized treatment with atypical antipsychotic drugs. The efficacy was measured at baseline and at the end of the study by the Brief Neuropsychological Examination 2 (ENB 2), the Mini Mental State Examination (MMSE), and the Stroop color-word interference test; the clinical symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS).</p><p><strong>Results: </strong>A final sample of nine patients completed the study. Regarding the cognitive performance, at the final assessment (week 2), the NF treatment significantly improved the performance in the \"Story Recall Immediate\" (p = 0.024), \"Story Recall Delayed\" (p = 0.007), \"Interference Memory 30 s\" (p = 0.024), \"Clock Test\" (p = 0.014) sub-tests, and the ENB2 Total Score (p = 0.007). Concerning the clinical symptoms, no significant changes were observed in the PANSS subscales and the PANSS Total score.</p><p><strong>Conclusions: </strong>NF could represent an adjunctive treatment strategy in the therapeutic toolbox for schizophrenia cognitive symptoms.</p>","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.1000,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486612/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"AIMS Neuroscience","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3934/Neuroscience.2024021","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Schizophrenia is characterized by significant cognitive impairments and affects up to 98% of patients. Neurofeedback (NF) offers a means to modulate neural network function through cognitive processes such as learning and memorization, with documented structural changes in the brain, most notably an increase in grey matter volume in targeted regions.

Methods: The present 2-week, open-label, preliminary study aims to evaluate the efficacy on cognition of an adjunctive short and intensive (8 daily sessions lasting 30 minutes) alpha/theta NF training in a sample of subjects affected by schizophrenia on stabilized treatment with atypical antipsychotic drugs. The efficacy was measured at baseline and at the end of the study by the Brief Neuropsychological Examination 2 (ENB 2), the Mini Mental State Examination (MMSE), and the Stroop color-word interference test; the clinical symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS).

Results: A final sample of nine patients completed the study. Regarding the cognitive performance, at the final assessment (week 2), the NF treatment significantly improved the performance in the "Story Recall Immediate" (p = 0.024), "Story Recall Delayed" (p = 0.007), "Interference Memory 30 s" (p = 0.024), "Clock Test" (p = 0.014) sub-tests, and the ENB2 Total Score (p = 0.007). Concerning the clinical symptoms, no significant changes were observed in the PANSS subscales and the PANSS Total score.

Conclusions: NF could represent an adjunctive treatment strategy in the therapeutic toolbox for schizophrenia cognitive symptoms.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
简短和强化神经反馈治疗对精神分裂症患者认知能力的影响:一项单中心试点研究。
背景:精神分裂症的特征是严重的认知障碍,高达 98% 的患者会受到影响。神经反馈(NF)提供了一种通过认知过程(如学习和记忆)调节神经网络功能的方法,并记录了大脑结构的变化,最显著的是目标区域灰质体积的增加:本研究是一项为期两周、开放标签的初步研究,旨在评估在接受非典型抗精神病药物稳定治疗的精神分裂症受试者样本中进行短期强化(每天 8 次,每次 30 分钟)α/θ NF 辅助训练对认知能力的影响。在基线和研究结束时,通过简短神经心理学检查 2 (ENB 2)、迷你精神状态检查 (MMSE) 和 Stroop 彩色单词干扰测试对疗效进行测量;通过阳性和阴性综合征量表 (PANSS) 对临床症状进行评估:最终有九名患者完成了研究。在认知表现方面,在最终评估(第2周)时,NF治疗显著改善了 "故事即时回忆"(p = 0.024)、"故事延迟回忆"(p = 0.007)、"30秒干扰记忆"(p = 0.024)、"时钟测试"(p = 0.014)子测试的表现,以及ENB2总分(p = 0.007)。在临床症状方面,PANSS分量表和PANSS总分均无明显变化:NF可作为精神分裂症认知症状治疗工具箱中的一种辅助治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
AIMS Neuroscience
AIMS Neuroscience NEUROSCIENCES-
CiteScore
4.20
自引率
0.00%
发文量
26
审稿时长
8 weeks
期刊介绍: AIMS Neuroscience is an international Open Access journal devoted to publishing peer-reviewed, high quality, original papers from all areas in the field of neuroscience. The primary focus is to provide a forum in which to expedite the speed with which theoretical neuroscience progresses toward generating testable hypotheses. In the presence of current and developing technology that offers unprecedented access to functions of the nervous system at all levels, the journal is designed to serve the role of providing the widest variety of the best theoretical views leading to suggested studies. Single blind peer review is provided for all articles and commentaries.
期刊最新文献
Vagus nerve stimulation in dementia: A scoping review of clinical and pre-clinical studies. The potential of exosomal biomarkers: Revolutionizing Parkinson's disease: How do they influence pathogenesis, diagnosis, and therapeutic strategies? The effects of right temporoparietal junction stimulation on embodiment, presence, and performance in teleoperation. Cognitive effects of brief and intensive neurofeedback treatment in schizophrenia: a single center pilot study. Novel perspective of therapeutic modules to overcome motor and nonmotor symptoms in Parkinson's disease.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1