Combining two injectable progesterone formulas for estrous synchronization in ewes.

IF 1.6 4区 农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE Animal Reproduction Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI:10.1590/1984-3143-AR2024-0073
Milena Luzorio Simões, Felipe Zandonadi Brandão, Juliana Dantas Rodrigues Santos, Pedro Henrique Nicolau Pinto, Ana Paula Pereira Schmidt, Camila Correa Roza Laeber, Nathália Dutra Knust, Mariana Garcia Kako Rodriguez, Danilo Fila, María Isabel Vázquez, Rodolfo Ungerfeld
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Abstract

The study aimed to evaluate the effectiveness of combining two injectable progesterone (iP4) formulas for estrous synchronization in ewes and to compare it with traditional intravaginal progesterone devices. Additionally, the study assessed whether the inclusion of GnRH enhances the reproductive outcomes of the iP4 treatment. Two experiments were conducted. In the first experiment, 20 Santa Inês ewes were divided into two groups: one group received intravaginal progesterone devices, and the other received combined long-acting and short-acting iP4. In the second experiment, 30 Corriedale ewes were divided into two groups: one received the combined iP4 with GnRH, and the other without GnRH. Estrous, ovulation, follicular populations, and progesterone concentrations were monitored. The combined iP4 treatment induced an artificial luteal phase and produced reproductive responses similar to those obtained with intravaginal devices. In the first experiment, the iP4 treatment tended to result in more synchronized ovulation compared to the control (P=0.095). In the second experiment, adding GnRH enhanced the quality of the corpus luteum, as indicated by increased diameter and vascularization on Day 23 (P=0.047 and P=0.02, respectively). The combined administration of long-acting and short-acting iP4 effectively synchronized estrous in ewes and showed similar efficacy to traditional intravaginal devices. The inclusion of GnRH improved luteal quality, suggesting potential benefits for reproductive management in ewes. Further studies are needed to evaluate the fertility outcomes of these protocols under field conditions.

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将两种可注射的黄体酮配方结合使用,实现母羊发情同步。
该研究旨在评估结合两种注射用黄体酮(iP4)配方对母羊发情同步的有效性,并将其与传统的阴道内黄体酮装置进行比较。此外,该研究还评估了 GnRH 的加入是否能提高 iP4 治疗的繁殖效果。共进行了两次实验。在第一项实验中,20头Santa Inês母羊被分为两组:一组接受阴道内黄体酮装置,另一组接受长效和短效iP4联合治疗。在第二项实验中,30 只科里代尔母羊被分为两组:一组接受联合 iP4 和 GnRH,另一组不接受 GnRH。对发情、排卵、卵泡数量和孕酮浓度进行了监测。联合 iP4 治疗诱导了人工黄体期,并产生了与阴道内装置类似的生殖反应。在第一个实验中,与对照组相比,iP4 处理往往会导致更多的同步排卵(P=0.095)。在第二个实验中,添加 GnRH 可提高黄体的质量,这表现在第 23 天黄体直径和血管增加(分别为 P=0.047 和 P=0.02)。长效和短效iP4联合给药能有效地同步母羊的发情,其效果与传统的阴道内装置相似。GnRH的加入改善了黄体质量,这表明iP4对母羊的繁殖管理具有潜在的益处。还需要进一步研究,以评估这些方案在田间条件下的繁殖效果。
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来源期刊
Animal Reproduction
Animal Reproduction AGRICULTURE, DAIRY & ANIMAL SCIENCE-
CiteScore
2.30
自引率
11.80%
发文量
49
审稿时长
70 days
期刊介绍: Animal Reproduction (AR) publishes original scientific papers and invited literature reviews, in the form of Basic Research, Biotechnology, Applied Research and Review Articles, with the goal of contributing to a better understanding of phenomena related to animal reproduction. The scope of the journal applies to students, researchers and practitioners in the fields of veterinary, biology and animal science, also being of interest to practitioners of human medicine. Animal Reproduction Journal is the official organ of the Brazilian College of Animal Reproduction in Brazil.
期刊最新文献
Chilled storage of Pacific white shrimp (Litopenaeus vannamei) spermatophores for assisted insemination. Withanolide derivatives: natural compounds with anticancer potential offer low toxicity to fertility and ovarian follicles in mice. First isolation and characterization of caprine oviduct fluid extracellular vesicles. Combining two injectable progesterone formulas for estrous synchronization in ewes. Too late or too soon? The replacement gilt paradox.
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