Improvements on speed, stability and field of view in adaptive optics OCT for anterior retinal imaging using a pyramid wavefront sensor.

IF 2.9 2区 医学 Q2 BIOCHEMICAL RESEARCH METHODS Biomedical optics express Pub Date : 2024-09-30 eCollection Date: 2024-10-01 DOI:10.1364/BOE.533451
Elisabeth Brunner, Laura Kunze, Victoria Laidlaw, Daniel Jodlbauer, Wolfgang Drexler, Ronny Ramlau, Andreas Pollreisz, Michael Pircher
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Abstract

We present improvements on the adaptive optics (AO) correction method using a pyramid wavefront sensor (P-WFS) and introduce a novel approach for closed-loop focus shifting in retinal imaging. The method's efficacy is validated through in vivo adaptive optics optical coherence tomography (AO-OCT) imaging in both, healthy individuals and patients with diabetic retinopathy. In both study groups, a stable focusing on the anterior retinal layers is achieved. We further report on an improvement in AO loop speed that can be used to expand the imaging area of AO-OCT in the slow scanning direction, largely independent of the eye's isoplanatic patch. Our representative AO-OCT data reveal microstructural details of the neurosensory retina such as vessel walls and microglia cells that are visualized in single volume data and over an extended field of view. The excellent performance of the P-WFS based AO-OCT imaging in patients suggests good clinical applicability of this technology.

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利用金字塔波前传感器改进用于视网膜前部成像的自适应光学 OCT 的速度、稳定性和视野。
我们对使用金字塔波前传感器(P-WFS)的自适应光学(AO)校正方法进行了改进,并引入了一种在视网膜成像中进行闭环焦点移动的新方法。通过对健康人和糖尿病视网膜病变患者进行活体自适应光学光学相干断层扫描(AO-OCT)成像,验证了该方法的有效性。在这两个研究小组中,都实现了对视网膜前层的稳定聚焦。我们进一步报告了 AO 循环速度的改进,该速度可用于扩大 AO-OCT 在慢速扫描方向上的成像区域,这在很大程度上与眼睛的等平面斑块无关。我们具有代表性的 AO-OCT 数据揭示了神经感觉视网膜的微观结构细节,如血管壁和小胶质细胞,这些细节在单体数据和扩展视场中均可视化。基于 P-WFS 的 AO-OCT 成像在患者身上的出色表现表明,这项技术具有良好的临床应用前景。
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来源期刊
Biomedical optics express
Biomedical optics express BIOCHEMICAL RESEARCH METHODS-OPTICS
CiteScore
6.80
自引率
11.80%
发文量
633
审稿时长
1 months
期刊介绍: The journal''s scope encompasses fundamental research, technology development, biomedical studies and clinical applications. BOEx focuses on the leading edge topics in the field, including: Tissue optics and spectroscopy Novel microscopies Optical coherence tomography Diffuse and fluorescence tomography Photoacoustic and multimodal imaging Molecular imaging and therapies Nanophotonic biosensing Optical biophysics/photobiology Microfluidic optical devices Vision research.
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