A case report of adolescent lactation due to the drug blonanserin.

IF 3.4 2区医学 Q2 PSYCHIATRY BMC Psychiatry Pub Date : 2024-10-18 DOI:10.1186/s12888-024-06118-y

Peiyuan Tang, Chongze Wang, Wu Hong, Zhenghui Yi, Qinyu Lv

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Abstract

Background: Second-generation antipsychotic drugs are increasingly used to treat depressive disorders with psychotic symptoms. In addition to effectively managing psychotic symptoms, second-generation antipsychotics can also result in adverse drug reactions in patients, which should not be underestimated.

Case presentation: We report the case of 14 years old unmarried female patient with depression. At first, she started with moping and gradually developed into self-injury and whispering. After antidepressant treatment combined with the second-generation antipsychotic drug blonanserin, the patient's psychotic and depressive symptoms improved significantly, while the patient developed lactation, which stopped after the medication was changed.

Conclusions: Although Blonanserin's clinical trials have reported rare adverse reactions like elevated prolactin levels and even lactation, caution is still needed in clinical application of the drug. This case is expected to improve psychiatrists' choice of antidepressant therapy in combination with antipsychotic drugs.

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一例因服用布隆色林而导致青春期泌乳的病例报告。

背景：第二代抗精神病药物越来越多地用于治疗伴有精神病性症状的抑郁症。第二代抗精神病药物除了能有效控制精神病性症状外，还可能导致患者出现药物不良反应，这一点不容小觑：我们报告了一例 14 岁的未婚女性抑郁症患者。病例介绍：我们报告了一例 14 岁的未婚女性抑郁症患者，起初她闷闷不乐，逐渐发展为自伤和低语。在联合使用第二代抗精神病药物布南色林进行抗抑郁治疗后，患者的精神症状和抑郁症状明显改善，同时患者出现了泌乳现象，在换药后泌乳现象停止：虽然布洛南色林的临床试验中出现了催乳素水平升高甚至泌乳等罕见不良反应，但在临床应用中仍需谨慎。本病例有望改善精神科医生对抗抑郁药物与抗精神病药物联合治疗的选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Psychiatry 医学-精神病学

CiteScore

5.90

自引率

4.50%

发文量

716

审稿时长

3-6 weeks

期刊介绍： BMC Psychiatry is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of psychiatric disorders, as well as related molecular genetics, pathophysiology, and epidemiology.