Extending insights from LeDoux: using movies to study subjective, clinically meaningful experiences in neuroscience.

IF 2.9 2区 医学 Q2 NEUROSCIENCES Cerebral cortex Pub Date : 2024-10-18 DOI:10.1093/cercor/bhae422
Peter A Kirk, Daniel S Pine, Katharina Kircanski
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Abstract

Neuroscience research with public health relevance to emotional disorders examines brain-behavior relations. Joe LeDoux's legacy advances these efforts in ways that remain truly unique. While recognized for his basic science research, he also inspires applied researchers, guiding an agenda for clinical scientists: understanding the pathophysiology of altered subjective experiences in emotional disorders. For brain imaging, movie-watching approaches help clinicians realize this agenda due to movies' relative strength in evoking rich, meaningful subjective experiences. Here, we describe methodological advances in movie-watching paradigms that might sustain LeDoux's impact by facilitating the discovery of neural mechanisms generating complex emotional responses. Of note, while linking subjective emotion to pathophysiology is a first step, innovations in movie-watching designs, especially involving therapeutic techniques for emotional disorders, can boost clinical application. Leveraging research on pathophysiology to generate novel therapy reflects the clinical legacy sustained through Joe LeDoux's rousing career.

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扩展勒杜的见解:利用电影研究神经科学中具有临床意义的主观体验。
与情绪失调的公共卫生相关的神经科学研究探讨了大脑与行为之间的关系。乔-勒杜的遗产以真正独特的方式推动着这些工作。虽然他的基础科学研究得到了认可,但他也激励着应用研究人员,为临床科学家指引了一项议程:了解情绪障碍中主观体验改变的病理生理学。在脑成像方面,由于电影在唤起丰富、有意义的主观体验方面具有相对优势,因此观看电影的方法有助于临床医生实现这一议程。在此,我们将介绍观影范式在方法论上的进步,这些进步可能会通过促进发现产生复杂情绪反应的神经机制来保持勒杜的影响力。值得注意的是,虽然将主观情绪与病理生理学联系起来是第一步,但观影设计的创新,尤其是涉及情绪障碍治疗技术的创新,可以促进临床应用。利用病理生理学研究产生新的治疗方法,体现了乔-勒杜令人振奋的职业生涯所带来的临床遗产。
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来源期刊
Cerebral cortex
Cerebral cortex 医学-神经科学
CiteScore
6.30
自引率
8.10%
发文量
510
审稿时长
2 months
期刊介绍: Cerebral Cortex publishes papers on the development, organization, plasticity, and function of the cerebral cortex, including the hippocampus. Studies with clear relevance to the cerebral cortex, such as the thalamocortical relationship or cortico-subcortical interactions, are also included. The journal is multidisciplinary and covers the large variety of modern neurobiological and neuropsychological techniques, including anatomy, biochemistry, molecular neurobiology, electrophysiology, behavior, artificial intelligence, and theoretical modeling. In addition to research articles, special features such as brief reviews, book reviews, and commentaries are included.
期刊最新文献
My science and career with Joseph E. LeDoux. Individual differences in functional connectivity during suppression of imagined threat. When emotion and time meet from human and rodent perspectives: a central role for the amygdala? Introspective psychophysics for the study of subjective experience. Examining threat responses through a developmental lens.
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