Nutrigenomics-guided lifestyle intervention programmes: A critical scoping review with directions for future research

IF 2.9 Q3 NUTRITION & DIETETICS Clinical nutrition ESPEN Pub Date : 2024-10-18 DOI:10.1016/j.clnesp.2024.10.149
Saba Aljasir , Noura M.S. Eid , Emanuela V. Volpi , Ihab Tewfik
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Abstract

Genetic testing is increasingly used in clinical practice to provide personalized information and recommendations about health risks and lifestyle habits at a relatively low cost. Research on the effectiveness of nutrigenomics-guided lifestyle interventions is growing. A scoping review approach was adopted to identify pertinent published studies on nutrigenomics-guided intervention programmes from 2007 to 2023. The review shows that despite the growing interest in nutrigenomics-guided lifestyle interventions, there are still few empirically supported studies, primarily based on developed countries. Furthermore, the findings on the impact of personalised genetic advice are mixed, leaving the field unclear. Existing studies have some empirical strength, contributing to further understanding of the relationship between food and gene expression. However, some limitations that affect the robustness of findings exist, such as a small sample size, insufficient monitoring of the data collection process, and a short follow-up period. Future research needs to address reliability concerns and provide more robust practical evidence.
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营养基因组学指导下的生活方式干预计划:重要范围综述与未来研究方向。
基因检测越来越多地应用于临床实践,以相对较低的成本提供有关健康风险和生活习惯的个性化信息和建议。有关以营养基因组学为指导的生活方式干预措施有效性的研究正在不断增加。我们采用了范围综述的方法,以确定从 2007 年到 2023 年发表的有关营养基因组学指导下的干预计划的相关研究。综述显示,尽管人们对营养基因组学指导下的生活方式干预越来越感兴趣,但有经验支持的研究仍然很少,而且主要是基于发达国家的研究。此外,关于个性化基因建议的影响的研究结果也是喜忧参半,使该领域的研究尚不明确。现有研究具有一定的经验优势,有助于进一步了解食物与基因表达之间的关系。不过,也存在一些影响研究结果稳健性的局限性,如样本量较小、对数据收集过程的监控不足、随访时间较短等。未来的研究需要解决可靠性问题,并提供更有力的实际证据。
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来源期刊
Clinical nutrition ESPEN
Clinical nutrition ESPEN NUTRITION & DIETETICS-
CiteScore
4.90
自引率
3.30%
发文量
512
期刊介绍: Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.
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