Clinicopathological features associated with CD44 and CD63 expression in breast cancer.

IF 1.2 Q4 ONCOLOGY ecancermedicalscience Pub Date : 2024-09-26 eCollection Date: 2024-01-01 DOI:10.3332/ecancer.2024.1779

Carlos A Castaneda, Miluska Castillo, Joselyn Sanchez, Luis Bernabe, Katherin Tello, Nancy Suarez, Raul Alatrista, Ximena Quiroz-Gil, Alexandra Granda-Oblitas, Javier Enciso, Nathaly Enciso, Henry L Gomez

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Abstract

Background: CD44 is a cell-surface transmembrane glycoprotein that participates in the regulation of many cellular processes, including cell division, adhesion, migration and stem-like characteristics. CD63 is involved in the exocytosis process.

Objective: To evaluate the relationship between CD44 and CD63 expression and clinicopathological features, including tumor-infiltrating lymphocytes (TILs), phosphoinositide 3-kinase (PIK3CA) mutation and survival.

Methodology: CD44 and CD63 were stained in samples from 101 breast cancer cases from Peruvian women.

Results: Median age was 52 years, most were most were grade-3 (68%), estrogen receptor (ER)+ (64%) and stage II-III (92%). Median ki67 was 30%, median stromal TIL was 30% and PIK3CA mutation was found in 49%. Longer survival was associated with earlier stages (p = 0.016), lower ki67 (p = 0.023), ER+ (p = 0.034), luminal phenotype (p = 0.029) and recurrence (p < 0.001). CD44 was classified as high cell density staining in 57% and high intensity in 55%. High CD44 density was associated with younger age (p = 0.043), triple-negative phenotype (p = 0.035) and shorter survival (p = 0.005). High CD44 expression was associated with short survival (p = 0.005). High CD63 cell density was found in 56% of cases and was associated with ER-positive (p = 0.045), low TIL levels (p = 0.007), Luminal-A (p = 0.015) and low CD44 intensity (p = 0.032).

Conclusion: CD44 expression was associated with aggressive features and low CD63 density staining.

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与乳腺癌中 CD44 和 CD63 表达相关的临床病理特征

背景：CD44是一种细胞表面跨膜糖蛋白，参与调控许多细胞过程，包括细胞分裂、粘附、迁移和干样特征。目的：评估 CD44 与 CD63 之间的关系：目的：评估 CD44 和 CD63 表达与临床病理特征（包括肿瘤浸润淋巴细胞（TILs）、磷酸肌酸 3- 激酶（PIK3CA）突变和存活率）之间的关系：方法：对来自秘鲁妇女的 101 例乳腺癌样本进行 CD44 和 CD63 染色：中位年龄为52岁，大多数为3级（68%）、雌激素受体（ER）+（64%）和II-III期（92%）。ki67中位数为30%，基质TIL中位数为30%，49%发现PIK3CA突变。较长的生存期与较早的分期（p = 0.016）、较低的ki67（p = 0.023）、ER+（p = 0.034）、管腔表型（p = 0.029）和复发（p < 0.001）有关。57% 的 CD44 被归类为高细胞密度染色，55% 的 CD44 被归类为高强度染色。CD44高密度与年龄较小（p = 0.043）、三阴表型（p = 0.035）和生存期较短（p = 0.005）有关。CD44 高表达与生存期短（p = 0.005）相关。56%的病例发现CD63细胞密度高，与ER阳性（p = 0.045）、TIL水平低（p = 0.007）、Luminal-A（p = 0.015）和CD44强度低（p = 0.032）有关：结论：CD44表达与侵袭性特征和低CD63密度染色相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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