Ryan Alexander, Blake Kassmeyer, Ryan Lennon, Jeffrey Alexander, Diana Snyder, Karthik Ravi
{"title":"EoE Recurrence on PPI Maintenance Therapy: You Do Not Know if You Do Not Look!","authors":"Ryan Alexander, Blake Kassmeyer, Ryan Lennon, Jeffrey Alexander, Diana Snyder, Karthik Ravi","doi":"10.1007/s10620-024-08676-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and aims: </strong>Data regarding histologic recurrence of EoE on PPI maintenance therapy are lacking.</p><p><strong>Methods: </strong>Retrospective review of 101 patients with histologic PPI-responsive EoE.</p><p><strong>Results: </strong>52/101 (51%) patients underwent follow-up EGD with biopsies. Of the 52 patients, 29 (56%) maintained histologic remission and 23 (44%) had histologic recurrence. 21 (40%) patients maintained BID PPI, 20 (39%) tapered to QD, and 11 (21%) had discontinued PPI. Of the 21 patients on BID PPI, 7 (33%) had histologic recurrence, of which 6 (86%) were asymptomatic.</p><p><strong>Conclusions: </strong>Patients on PPI therapy for EoE benefit from serial clinical, endoscopic, and histologic surveillance.</p>","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":"4048-4052"},"PeriodicalIF":2.5000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Digestive Diseases and Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10620-024-08676-3","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/15 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background and aims: Data regarding histologic recurrence of EoE on PPI maintenance therapy are lacking.
Methods: Retrospective review of 101 patients with histologic PPI-responsive EoE.
Results: 52/101 (51%) patients underwent follow-up EGD with biopsies. Of the 52 patients, 29 (56%) maintained histologic remission and 23 (44%) had histologic recurrence. 21 (40%) patients maintained BID PPI, 20 (39%) tapered to QD, and 11 (21%) had discontinued PPI. Of the 21 patients on BID PPI, 7 (33%) had histologic recurrence, of which 6 (86%) were asymptomatic.
Conclusions: Patients on PPI therapy for EoE benefit from serial clinical, endoscopic, and histologic surveillance.
期刊介绍：
Digestive Diseases and Sciences publishes high-quality, peer-reviewed, original papers addressing aspects of basic/translational and clinical research in gastroenterology, hepatology, and related fields. This well-illustrated journal features comprehensive coverage of basic pathophysiology, new technological advances, and clinical breakthroughs; insights from prominent academicians and practitioners concerning new scientific developments and practical medical issues; and discussions focusing on the latest changes in local and worldwide social, economic, and governmental policies that affect the delivery of care within the disciplines of gastroenterology and hepatology.
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