A review of urinary HPV testing for cervical cancer management and HPV vaccine surveillance: rationale, strategies, and limitations.

IF 3.7 3区 医学 Q2 INFECTIOUS DISEASES European Journal of Clinical Microbiology & Infectious Diseases Pub Date : 2024-12-01 Epub Date: 2024-10-14 DOI:10.1007/s10096-024-04963-z
Lin Cheng, Ru Wang, Jing Yan
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Abstract

Human papillomavirus (HPV) infections are the leading cause of cervical cancer, the fourth most common cancer among women worldwide. Despite concerted efforts to combat this preventable disease through HPV vaccination and cancer screening have helped reduce morbidity and mortality levels, the burden persists in both developing and developed countries due to insufficient vaccination and screening coverage. Urinary HPV testing has emerged as a noninvasive detection method, offering significant advantages in cervical cancer management and vaccine surveillance. Notably, it boasts high acceptance rates, ease of self-collection, user-friendly implementation, and relatively low cost. Various urinary HPV detection methods have been explored, predominantly relying on nucleic acid amplification and signal amplification, targeting a variety of biomarkers in urine, such as HPV DNA, RNA, and oncoproteins. Existing literature underscores urine as a promising specimen for HPV testing, demonstrating comparable detection performance to cervical and vaginal samples in several studies. However, the lack of standardized and authoritative protocols in sample collection, storage, preparation, DNA extraction, and amplification necessitates further evaluation for the comprehensive utilization of urinary HPV testing in clinical and epidemiological settings. This study aims to review pertinent publications and offer insights into the rationale, common strategies, and limitations of urinary HPV testing, with the ultimate goal of maximizing its utility in practice.

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用于宫颈癌管理和 HPV 疫苗监测的尿液 HPV 检测综述:原理、策略和局限性。
人类乳头瘤病毒(HPV)感染是宫颈癌的主要病因,也是全球妇女第四大常见癌症。尽管通过接种人乳头瘤病毒疫苗和癌症筛查来防治这种可预防疾病的共同努力已帮助降低了发病率和死亡率,但由于疫苗接种和筛查覆盖率不足,发展中国家和发达国家的宫颈癌负担依然存在。尿液 HPV 检测已成为一种无创检测方法,在宫颈癌管理和疫苗监测方面具有显著优势。值得注意的是,它具有接受率高、易于自我采集、操作简便、成本相对较低等优点。目前已探索出多种尿液 HPV 检测方法,主要依赖于核酸扩增和信号扩增,针对尿液中的多种生物标记物,如 HPV DNA、RNA 和肿瘤蛋白。现有文献强调,尿液是一种很有前景的 HPV 检测样本,在多项研究中,尿液的检测性能与宫颈样本和阴道样本相当。然而,由于在样本采集、储存、制备、DNA 提取和扩增等方面缺乏标准化的权威方案,因此有必要对临床和流行病学环境中尿液 HPV 检测的综合利用进行进一步评估。本研究旨在回顾相关出版物,深入探讨尿液HPV检测的原理、常用策略和局限性,最终目标是最大限度地提高尿液HPV检测的实用性。
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来源期刊
CiteScore
10.40
自引率
2.20%
发文量
138
审稿时长
1 months
期刊介绍: EJCMID is an interdisciplinary journal devoted to the publication of communications on infectious diseases of bacterial, viral and parasitic origin.
期刊最新文献
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