{"title":"Chemical structures of polyketides and alkaloids isolated from a culture of fungus Curvularia moringae","authors":"Takahiro Matsumoto , Miho Hamai , Yayako Inui , Tomoe Ohta , Tatsusada Yoshida , Naoto Kojima , Hayato Yoshikawa , Raku Kutose , Shiori Ando , Tetsushi Watanabe","doi":"10.1016/j.fitote.2024.106263","DOIUrl":null,"url":null,"abstract":"<div><div>Seven new polyketides [moringols I–VII (<strong>1</strong>–<strong>7</strong>)], a new alkaloid [moringamine I (<strong>8</strong>)], and seven known compounds (<strong>9</strong>–<strong>15</strong>) were isolated from the fungus <em>Curvularia moringae</em> JKYM-KR4. The planar chemical structures and relative configurations of the new compounds were elucidated by high-resolution mass spectrometry, 1D and 2D NMR spectroscopy, and DP4+ analysis using the calculated <sup>13</sup>C NMR chemical shifts. For moringols I and II (<strong>1</strong> and <strong>2</strong>), the planar chemical structures and relative configurations were confirmed using X-ray crystallography. The absolute configurations of <strong>1</strong>–<strong>6</strong> and <strong>8</strong> were determined by ECD calculations. Among the isolated compounds, terpestacin (<strong>14</strong>) moderately inhibited the proliferation of HT-29 cells.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fitoterapia","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0367326X24004465","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Seven new polyketides [moringols I–VII (1–7)], a new alkaloid [moringamine I (8)], and seven known compounds (9–15) were isolated from the fungus Curvularia moringae JKYM-KR4. The planar chemical structures and relative configurations of the new compounds were elucidated by high-resolution mass spectrometry, 1D and 2D NMR spectroscopy, and DP4+ analysis using the calculated 13C NMR chemical shifts. For moringols I and II (1 and 2), the planar chemical structures and relative configurations were confirmed using X-ray crystallography. The absolute configurations of 1–6 and 8 were determined by ECD calculations. Among the isolated compounds, terpestacin (14) moderately inhibited the proliferation of HT-29 cells.
期刊介绍：
Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas:
1. Characterization of active ingredients of medicinal plants
2. Development of standardization method for bioactive plant extracts and natural products
3. Identification of bioactivity in plant extracts
4. Identification of targets and mechanism of activity of plant extracts
5. Production and genomic characterization of medicinal plants biomass
6. Chemistry and biochemistry of bioactive natural products of plant origin
7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
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