Tímea Bencsik , Viktória Lilla Balázs , Ágnes Farkas , Eszter Csikós , Adrienn Horváth , Kamilla Ács , Marianna Kocsis , Martin Doseděl , Silvia Bittner Fialová , Szilvia Czigle , Milan Nagy , Jaroslav Tóth , Michele Protti , Laura Mercolini , Přemysl Mladěnka , József Szentpéteri , Györgyi Horváth
{"title":"Herbal drugs in chronic venous disease treatment: An update","authors":"Tímea Bencsik , Viktória Lilla Balázs , Ágnes Farkas , Eszter Csikós , Adrienn Horváth , Kamilla Ács , Marianna Kocsis , Martin Doseděl , Silvia Bittner Fialová , Szilvia Czigle , Milan Nagy , Jaroslav Tóth , Michele Protti , Laura Mercolini , Přemysl Mladěnka , József Szentpéteri , Györgyi Horváth","doi":"10.1016/j.fitote.2024.106256","DOIUrl":null,"url":null,"abstract":"<div><div>The prevalence of chronic venous disease (CVD) is relatively high, it affects 20–80 % of the population worldwide. CVD may affect any veins in the human body, however, the veins of the lower extremities are the most susceptible to this condition. Among therapeutic possibilities for CVD, mainly chronic venous insufficiency, some medicinal plants (<em>Ruscus aculeatus</em> L., <em>Aesculus hippocastanum</em> L., <em>Centella asiatica</em> (L.) Urb.) and their active compounds (ruscoside, aescin, asiaticoside) or close derivatives also have important places. This review describes shortly the updated knowledge on pathophysiology, clinical manifestations, evaluation, and diagnostics of CVD as well as treatment modalities. The primary focus of this review is on the existing knowledge about botanical medications for treating chronic venous disease (CVD). It covers the chemical makeup of these plant drugs, their pharmacological effects, results from clinical trials involving humans, and any associated safety concerns.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fitoterapia","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0367326X24004398","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
The prevalence of chronic venous disease (CVD) is relatively high, it affects 20–80 % of the population worldwide. CVD may affect any veins in the human body, however, the veins of the lower extremities are the most susceptible to this condition. Among therapeutic possibilities for CVD, mainly chronic venous insufficiency, some medicinal plants (Ruscus aculeatus L., Aesculus hippocastanum L., Centella asiatica (L.) Urb.) and their active compounds (ruscoside, aescin, asiaticoside) or close derivatives also have important places. This review describes shortly the updated knowledge on pathophysiology, clinical manifestations, evaluation, and diagnostics of CVD as well as treatment modalities. The primary focus of this review is on the existing knowledge about botanical medications for treating chronic venous disease (CVD). It covers the chemical makeup of these plant drugs, their pharmacological effects, results from clinical trials involving humans, and any associated safety concerns.
期刊介绍:
Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas:
1. Characterization of active ingredients of medicinal plants
2. Development of standardization method for bioactive plant extracts and natural products
3. Identification of bioactivity in plant extracts
4. Identification of targets and mechanism of activity of plant extracts
5. Production and genomic characterization of medicinal plants biomass
6. Chemistry and biochemistry of bioactive natural products of plant origin
7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.