The Levels of Serum HBV Pre-Genomic RNA and Its Associated Factors Among HBV-Infected Patients: A Retrospective Cohort Study in Hangzhou, Zhejiang, China.

IF 2.1 4区医学 Q2 MEDICINE, GENERAL & INTERNAL International Journal of General Medicine Pub Date : 2024-10-15 eCollection Date: 2024-01-01 DOI:10.2147/IJGM.S480283

Zhongbao Zuo, Jing Wu, Miaochan Wang, Rui Wu, Xiaojing Zhang, Lanlan Hu, Huaizhong Cui, Ting Feng, Aifang Xu, Shourong Liu

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Abstract

Introduction: This study aimed to explore serum HBV pre-genomic RNA (pgRNA) levels and its associated factors among HBV-infected patients in the real world.

Methods: This retrospective cohort study was conducted from May 10, 2023, to January 15, 2024. Univariate logistic analysis for positive serum HBV pgRNA was performed first, and variables with statistical significance were included in a multivariate logistic model. A decreasing trend of serum HBV pgRNA and HBV DNA levels was also detected first by univariate logistic regression and then by multivariate logistic regression.

Results: 482 patients were included in our analysis at baseline, and 191 patients were followed up. Multivariate logistic regression revealed that positive HBV DNA (AOR: 2.63, 95% CI: 1.46-4.75, P=0.001), ≥1000 hBsAg (AOR: 2.29, 95% CI: 1.08-4.89, P=0.03), positive HBeAg (AOR: 28.26, 95% CI: 15.2-52.55, P<0.001), and ALP (AOR: 1.01, 95% CI: 1.001-1.02, P=0.03) were positively correlated with positive HBV pgRNA at baseline. Two independent multivariate logistic regression models were constructed for the decreasing trend of serum HBV pgRNA and HBV DNA for the 191 follow-up patients. Results showed that the decreasing trend of HBV pgRNA was positively correlated with positive baseline HBV DNA (AOR: 4.60, 95% CI: 1.84-11.51, P=0.001), baseline HBsAg ≥1000 IU/mL (AOR: 8.74, 95% CI: 1.09-70.10, P=0.04), and HDL (AOR: 5.01, 95% CI: 1.28-19.66, P=0.02). The decreasing trend of HBV DNA was positively correlated with positive baseline HBV pgRNA (AOR: 3.80, 95% CI: 2.00-8.83, P<0.001) and AST (AOR: 1.06, 95% CI: 1.03-1.08, P<0.001).

Conclusion: Our study revealed that HBV DNA, HBsAg, HBeAg, and ALP were significantly correlated with positive HBV pgRNA at baseline. The baseline HBV DNA, HBsAg, and HDL were significantly correlated with decreasing levels of HBV pgRNA. A decreasing trend of HBV DNA significantly correlated with patients' baseline HBV pgRNA and AST.

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HBV 感染者血清 HBV 前基因组 RNA 水平及其相关因素：中国浙江杭州的一项回顾性队列研究。

引言本研究旨在探讨现实世界中 HBV 感染者的血清 HBV 前基因组 RNA（pgRNA）水平及其相关因素：这项回顾性队列研究于 2023 年 5 月 10 日至 2024 年 1 月 15 日进行。首先对血清 HBV pgRNA 阳性进行单变量逻辑分析，然后将具有统计学意义的变量纳入多变量逻辑模型。首先通过单变量逻辑回归，然后通过多变量逻辑回归，检测血清 HBV pgRNA 和 HBV DNA 水平的下降趋势：基线分析共纳入 482 例患者，并对 191 例患者进行了随访。多变量逻辑回归显示，HBV DNA 阳性（AOR：2.63，95% CI：1.46-4.75，P=0.001）、≥1000 hBsAg（AOR：2.29，95% CI：1.08-4.89，P=0.03）、HBeAg 阳性（AOR：28.26，95% CI：15.2-52.55，PConclusion：我们的研究显示，HBV DNA、HBsAg、HBeAg 和 ALP 与基线 HBV pgRNA 阳性显著相关。基线 HBV DNA、HBsAg 和 HDL 与 HBV pgRNA 水平的下降呈显著相关。HBV DNA 的下降趋势与患者的基线 HBV pgRNA 和 AST 显著相关。

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来源期刊

International Journal of General Medicine Medicine-General Medicine

自引率

0.00%

发文量

1113

审稿时长

16 weeks

期刊介绍： The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.