Coronary artery bypass grafting in dialysis patients: a propensity score-matched analysis.

IF 1.5 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Journal of Cardiothoracic Surgery Pub Date : 2024-10-16 DOI:10.1186/s13019-024-03102-1
Jingfang Xu, Yumeng Wang, Cheng Chen, Lifang Zhang, Xiaofeng Cheng, Xueyan Bian, Jiaxin Ye
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Abstract

Background: Patients undergoing dialysis treatment have long been recognized as having an elevated risk of developing coronary artery disease necessitating coronary artery bypass grafting (CABG). However, the prognostic implications of CABG in dialysis-dependent patients remain underexplored. This study aimed to comprehensively assess both short- and long-term outcomes in dialysis-dependent patients undergoing CABG.

Methods: In this retrospective analysis, we meticulously matched 55 dialysis-dependent patients with 55 non-dialysis patients, controlling for baseline characteristics including age, sex, etiology, and date of surgery. All patients underwent CABG treatment at our institution between January 2014 and June 2022. We conducted a comparative analysis of postoperative complications and survival rates between the two groups.

Results: Our findings revealed that the dialysis-dependent group exhibited a significantly higher incidence of postoperative complications compared to the non-dialysis group (92.7% vs. 61.8%; p < 0.001). Furthermore, the 5-year survival rates were notably diminished among dialysis patients relative to their non-dialysis counterparts (46.2 ± 7.9% vs. 58.2 ± 12.1%, p = 0.045). Consistently, dialysis patients exhibited decreased 5-year cardiac-event-free rates in contrast to non-dialysis patients (31.6 ± 7.6% vs. 58.8 ± 11.3%, p = 0.041). Predictably, several baseline parameters were identified as significant risk factors contributing to adverse outcomes among dialysis patients, including a history of smoking, diabetes mellitus, congestive heart failure upon admission, and the requirement for intraoperative concomitant surgery (p = 0.006, p = 0.043, p = 0.017, p = 0.003, respectively).

Conclusions: This study underscores the poorer prognosis associated with CABG treatment in dialysis-dependent patients. Notably, baseline factors such as a smoking history, diabetes mellitus, congestive heart failure upon admission, and the need for intraoperative concomitant surgery were all independently linked to increased mortality in this patient population.

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透析患者的冠状动脉旁路移植术:倾向得分匹配分析。
背景:长期以来,人们一直认为接受透析治疗的患者罹患冠状动脉疾病的风险较高,需要进行冠状动脉旁路移植术(CABG)。然而,透析依赖患者接受冠状动脉旁路移植术的预后影响仍未得到充分探讨。本研究旨在全面评估接受 CABG 的透析依赖患者的短期和长期预后:在这项回顾性分析中,我们对 55 名透析依赖患者和 55 名非透析患者进行了细致的配对,并控制了年龄、性别、病因和手术日期等基线特征。所有患者均于 2014 年 1 月至 2022 年 6 月期间在我院接受了 CABG 治疗。我们对两组患者的术后并发症和存活率进行了比较分析:结果:我们的研究结果显示,与非透析组相比,透析依赖组的术后并发症发生率明显更高(92.7% vs. 61.8%;P 结论:透析依赖组患者的术后并发症发生率明显高于非透析组(92.7% vs. 61.8%;P):本研究强调了透析依赖患者接受 CABG 治疗的预后较差。值得注意的是,吸烟史、糖尿病、入院时充血性心力衰竭以及术中需要同时进行手术等基线因素都与这一患者群体死亡率的增加有独立联系。
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来源期刊
Journal of Cardiothoracic Surgery
Journal of Cardiothoracic Surgery 医学-心血管系统
CiteScore
2.50
自引率
6.20%
发文量
286
审稿时长
4-8 weeks
期刊介绍: Journal of Cardiothoracic Surgery is an open access journal that encompasses all aspects of research in the field of Cardiology, and Cardiothoracic and Vascular Surgery. The journal publishes original scientific research documenting clinical and experimental advances in cardiac, vascular and thoracic surgery, and related fields. Topics of interest include surgical techniques, survival rates, surgical complications and their outcomes; along with basic sciences, pediatric conditions, transplantations and clinical trials. Journal of Cardiothoracic Surgery is of interest to cardiothoracic and vascular surgeons, cardiothoracic anaesthesiologists, cardiologists, chest physicians, and allied health professionals.
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