The effects of digoxin on heart failure mortality and re-admission in a single center cross-sectional study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-01-01 Epub Date: 2024-09-20 DOI:10.34172/jcvtr.33062

Mahsa Behnemoon, Zahra Borumandkia

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Abstract

Introduction: Mortality benefit of digoxin prescription in patients suffering from heart failure has been questioned many time. We evaluated these effects among admitted symptomatic heart failure patients.

Methods: We retrospectively divided our patients into two groups: group A (n=205) were digoxin prescribed, and group B (n=96) were digoxin naïve patients. Both groups' medical records were gathered for one year, and the study endpoints were compared between the two groups.

Results: The mean age was 62.3±12.1 years and 54.8 % were male. All-cause mortality and readmission occurred in 26.7% and 31.7% of individuals, respectively, without significant differences between the two groups. However, in subgroup analysis, there was a significant relationship between in-hospital mortality and the presence of cardiovascular risk factors.

Conclusion: Digoxin might increase in-hospital mortality in patients with underlying cardiovascular risk factors.

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一项单中心横断面研究显示，地高辛对心力衰竭死亡率和再入院率的影响。

导言心力衰竭患者服用地高辛可降低死亡率，这一点曾多次受到质疑。我们对入院的无症状心衰患者进行了评估：我们回顾性地将患者分为两组：A 组（205 人）为地高辛处方患者，B 组（96 人）为地高辛无处方患者。收集两组患者一年的病历资料，比较两组患者的研究终点：平均年龄为（62.3±12.1）岁，54.8%为男性。全因死亡率和再入院率分别为 26.7% 和 31.7%，两组之间无明显差异。然而，在亚组分析中，院内死亡率与是否存在心血管风险因素之间存在显著关系：结论：地高辛可能会增加存在潜在心血管风险因素的患者的院内死亡率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.