The crosstalk between primary MSCs and cancer cells in 2D and 3D cultures: potential therapeutic strategies and impact on drug resistance.

IF 5.4 2区医学 Q1 CELL & TISSUE ENGINEERING Stem Cells Translational Medicine Pub Date : 2024-10-10 DOI:10.1093/stcltm/szae077

Ayesha Rehman, Sameer Kumar Panda, Martina Torsiello, Martina Marigliano, Camilla Carmela Tufano, Aditya Nigam, Zahida Parveen, Gianpaolo Papaccio, Marcella La Noce

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Abstract

The tumor microenvironment (TME) significantly influences cancer progression, and mesenchymal stem cells (MSCs) play a crucial role in interacting with tumor cells via paracrine signaling, affecting behaviors such as proliferation, migration, and epithelial-mesenchymal transition. While conventional 2D culture models have provided valuable insights, they cannot fully replicate the complexity and diversity of the TME. Therefore, developing 3D culture systems that better mimic in vivo conditions is essential. This review delves into the heterogeneous nature of the TME, spotlighting MSC-tumor cellular signaling and advancements in 3D culture technologies. Utilizing MSCs in cancer therapy presents opportunities to enhance treatment effectiveness and overcome resistance mechanisms. Understanding MSC interactions within the TME and leveraging 3D culture models can advance novel cancer therapies and improve clinical outcomes. Additionally, this review underscores the therapeutic potential of engineered MSCs, emphasizing their role in targeted anti-cancer treatments.

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原代间充质干细胞与癌细胞在二维和三维培养物中的相互作用：潜在的治疗策略及其对耐药性的影响。

肿瘤微环境（TME）对癌症进展有重大影响，间充质干细胞（MSCs）通过旁分泌信号与肿瘤细胞相互作用，影响肿瘤细胞的增殖、迁移和上皮-间充质转化等行为。虽然传统的二维培养模型提供了有价值的见解，但它们无法完全复制肿瘤组织间质的复杂性和多样性。因此，开发能更好地模拟体内条件的三维培养系统至关重要。本综述将深入探讨肿瘤组织间充质干细胞的异质性，重点介绍间充质干细胞-肿瘤细胞信号传导以及三维培养技术的进展。在癌症治疗中利用间充质干细胞为提高治疗效果和克服抗药性机制提供了机会。了解间充质干细胞在肿瘤组织间质内的相互作用并利用三维培养模型可以推进新型癌症疗法并改善临床疗效。此外，这篇综述还强调了工程间充质干细胞的治疗潜力，强调了它们在靶向抗癌治疗中的作用。

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来源期刊

Stem Cells Translational Medicine CELL & TISSUE ENGINEERING-

CiteScore

12.90

自引率

3.30%

发文量

140

审稿时长

6-12 weeks

期刊介绍： STEM CELLS Translational Medicine is a monthly, peer-reviewed, largely online, open access journal. STEM CELLS Translational Medicine works to advance the utilization of cells for clinical therapy. By bridging stem cell molecular and biological research and helping speed translations of emerging lab discoveries into clinical trials, STEM CELLS Translational Medicine will help move applications of these critical investigations closer to accepted best patient practices and ultimately improve outcomes. The journal encourages original research articles and concise reviews describing laboratory investigations of stem cells, including their characterization and manipulation, and the translation of their clinical aspects of from the bench to patient care. STEM CELLS Translational Medicine covers all aspects of translational cell studies, including bench research, first-in-human case studies, and relevant clinical trials.