Effect of paternal overweight or obesity on semen parameters, clinical pregnancy and live birth outcomes in men treated with intrauterine insemination (IUI).
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Abstract
Background: Overweight and obese individuals are steadily increasing in recent years. Male overweight or obesity has adverse impact on reproductive functions. The study aimed to evaluate the potential impact of paternal overweight or obesity on sperm quality and clinical pregnancy outcome in patients undergoing intrauterine insemination (IUI) treatment.
Methods: This retrospective study included 1,036 couples from our reproductive center between July 2019 and August 2022. All males were categorized into normal weight, overweight, or obese groups according to their body mass index (BMI). Baseline characteristics and reproductive hormones were analyzed. Semen parameters, clinical pregnancy and live birth outcomes were compared among the different BMI groups.
Results: There were no significant differences in sperm concentration, total sperm motility, progressive sperm motility, normal sperm morphology and sperm DNA fragmentation index (DFI) among the three groups. However, the obese group exhibited a significantly decreased semen volume compared to the other two groups (P<0.01). No differences were found in clinical pregnancy rate (CPR), abortion rate (AR) and live birth rate (LBR) among the groups (P>0.05). Slight higher ARs were observed in overweight and obese groups compared to normal group (13.64%, 21.05% vs. 11.11%, P=0.49).
Conclusions: These data suggest that male obesity leads to a significant decrease in semen volume. It is thus recommended that male BMI should be regarded as one of the predictors for IUI treatment to avoid a decrease in semen volume.
背景：近年来，超重和肥胖的人数持续增加。男性超重或肥胖对生殖功能有不利影响。本研究旨在评估接受宫腔内人工授精（IUI）治疗的患者中，父亲超重或肥胖对精子质量和临床妊娠结局的潜在影响：这项回顾性研究纳入了我们生殖中心2019年7月至2022年8月期间的1036对夫妇。根据体重指数（BMI）将所有男性分为正常体重组、超重组和肥胖组。对基线特征和生殖激素进行了分析。比较了不同体重指数组的精液参数、临床妊娠和活产结果：结果：三个组别在精子浓度、精子总活力、精子渐进活力、精子正常形态和精子DNA碎片指数（DFI）方面没有明显差异。然而，肥胖组的精液量比其他两组明显减少（P0.05）。与正常组相比，超重组和肥胖组的ARs略高（13.64%、21.05% vs. 11.11%，P=0.49）：这些数据表明，男性肥胖会导致精液量显著减少。因此，建议将男性体重指数作为人工授精治疗的预测指标之一，以避免精液量减少。
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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