Perspective on donor-derived infections in Italy.

IF 2.6 4区医学 Q3 IMMUNOLOGY Transplant Infectious Disease Pub Date : 2024-11-01 Epub Date: 2024-10-15 DOI:10.1111/tid.14398

Paolo Antonio Grossi, Letizia Lombardini, Raffaele Donadio, Daniela Peritore, Giuseppe Feltrin

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Abstract

Background: Expected and unexpected donor-derived infections (DDI) are a rare event in solid organ transplant (SOT) recipients but are potentially associated with significant morbidity and mortality. To assure the microbial safety of transplantation, both national guidelines and the current, regional, and local epidemiology of infectious diseases must be considered.

Methods: In the present paper the strategies adopted by the Italian National Center for Transplantation (CNT) since 2003 and their evolution to guarantee the safety of organ transplantation are reported. Starting in 2012 mandatory reporting to the CNT of all adverse reactions was started. The number and type of DDI reported to the CNT are currently being analyzed.

Results: The infectious diseases second opinion has written and updated the guidelines on the safety of organs for transplantation and supported the Italian transplant network for the use of organs from donors with suspected or documented potentially transmissible infections.

Conclusion: A transplant safety network was developed in Italy in 2003 and has been updated according to the evolving knowledge and the changing epidemiology. This is an evolving field, and a continuous update of the recommendation is needed.

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透视意大利的供体源性感染。

背景：预期和意外的供体源性感染（DDI）在实体器官移植（SOT）受者中非常罕见，但却可能导致严重的发病率和死亡率。为确保移植的微生物安全性，必须考虑国家指导方针以及当前、地区和当地的传染病流行情况：本文报告了意大利国家器官移植中心（CNT）自 2003 年以来为确保器官移植安全而采取的策略及其演变情况。自2012年起，国家器官移植中心开始强制报告所有不良反应。目前正在分析向 CNT 报告的 DDI 数量和类型：结果：传染病第二意见撰写并更新了器官移植安全指南，并支持意大利移植网络使用疑似或记录有潜在传染病供体的器官：意大利于 2003 年建立了移植安全网络，并根据不断发展的知识和流行病学的变化进行了更新。这是一个不断发展的领域，需要不断更新建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transplant Infectious Disease 医学-传染病学

CiteScore

5.30

自引率

7.70%

发文量

210

审稿时长

4-8 weeks

期刊介绍： Transplant Infectious Disease has been established as a forum for presenting the most current information on the prevention and treatment of infection complicating organ and bone marrow transplantation. The point of view of the journal is that infection and allograft rejection (or graft-versus-host disease) are closely intertwined, and that advances in one area will have immediate consequences on the other. The interaction of the transplant recipient with potential microbial invaders, the impact of immunosuppressive strategies on this interaction, and the effects of cytokines, growth factors, and chemokines liberated during the course of infections, rejection, or graft-versus-host disease are central to the interests and mission of this journal. Transplant Infectious Disease is aimed at disseminating the latest information relevant to the infectious disease complications of transplantation to clinicians and scientists involved in bone marrow, kidney, liver, heart, lung, intestinal, and pancreatic transplantation. The infectious disease consequences and concerns regarding innovative transplant strategies, from novel immunosuppressive agents to xenotransplantation, are very much a concern of this journal. In addition, this journal feels a particular responsibility to inform primary care practitioners in the community, who increasingly are sharing the responsibility for the care of these patients, of the special considerations regarding the prevention and treatment of infection in transplant recipients. As exemplified by the international editorial board, articles are sought throughout the world that address both general issues and those of a more restricted geographic import.