Mohammad Fararouei, Farzaneh Mobasheri, Abbas Rahimi Jaberi, Jafar Hasanzadeh
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引用次数: 0
Abstract
Background: Several health, environmental, and lifestyle-related factors have been separately linked to multiple sclerosis (MS) by different studies. However, these studies did not adequately account for the temporal association of these factors with MS while considering the influence of other variables in the analysis. A comprehensive investigation of these factors remains scarce.
Methods: A hospital-based case-control study was carried out between Jun 2020 to Mar 2021 on 525 cases and 1050 controls frequently matched by age and sex. Cases and controls were selected at the same time and from the same centers (Motahari and Imam Reza referral centers) in Shiraz (the capital of Fars Province). Health, socio-demographic, and lifestyle status during adolescence were studied in this case-control study.
Results: The likelihood of having a history of autoimmune disease(s) (ORyes/no=15.67, P<0.001) and family history of MS (ORyes/no=11.57, P<0.001) were higher in cases. In addition, the likelihoods of reporting a history of head/neck traumas (ORhaving a history/no history=9.16, P<0.001), smoking (ORregular/other =2.24, P=0.008), and stressful events (ORyes/no=1.47, P=0.007) were higher among the case group. On the other hand, the odds of sun exposure (ORmost the time/seldom =0.14, P<0.001), physical activity (ORactive/inactive=0.45, P<0.001), and good quality sleep (OR=0.93, P<0.001) were significantly lower in the case group.
Conclusion: This study provided a broad picture of the factors associated with MS, most of which were modifiable. Positive alterations to these factors through social and health educational programs are likely to reduce the burden of MS in Iran.
背景：不同的研究已分别将一些健康、环境和生活方式相关因素与多发性硬化症（MS）联系起来。然而，这些研究并没有充分考虑这些因素与多发性硬化症的时间关联，同时在分析中也没有考虑其他变量的影响。对这些因素的全面调查仍然很少：2020年6月至2021年3月期间，对525例病例和1050例对照进行了医院病例对照研究。病例和对照组同时选自设拉子（法尔斯省首府）的同一中心（莫塔哈里和伊玛目礼萨转诊中心）。这项病例对照研究调查了青少年时期的健康、社会人口和生活方式状况：病例组患自身免疫性疾病（ORyes/no=15.67，Pyes/no=11.57，Phaving a history/no history=9.16，Pregular/other=2.24，P=0.008）和压力事件（ORyes/no=1.47，P=0.007）的几率更高。另一方面，晒太阳的几率（ORmost the time/seldom =0.14，Pactive/inactive=0.45，PPConclusion：这项研究提供了多发性硬化症相关因素的大致情况，其中大部分因素是可以改变的。通过社会和健康教育计划积极改变这些因素很可能会减轻多发性硬化症在伊朗的负担。
期刊介绍：
Iranian Journal of Public Health has been continuously published since 1971, as the only Journal in all health domains, with wide distribution (including WHO in Geneva and Cairo) in two languages (English and Persian). From 2001 issue, the Journal is published only in English language. During the last 41 years more than 2000 scientific research papers, results of health activities, surveys and services, have been published in this Journal. To meet the increasing demand of respected researchers, as of January 2012, the Journal is published monthly. I wish this will assist to promote the level of global knowledge. The main topics that the Journal would welcome are: Bioethics, Disaster and Health, Entomology, Epidemiology, Health and Environment, Health Economics, Health Services, Immunology, Medical Genetics, Mental Health, Microbiology, Nutrition and Food Safety, Occupational Health, Oral Health. We would be very delighted to receive your Original papers, Review Articles, Short communications, Case reports and Scientific Letters to the Editor on the above mentioned research areas.
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