Using precision approaches to improve brain-behavior prediction.

Abstract

Predicting individual behavioral traits from brain idiosyncrasies has broad practical implications, yet predictions vary widely. This constraint may be driven by a combination of signal and noise in both brain and behavioral variables. Here, we expand on this idea, highlighting the potential of extended sampling 'precision' studies. First, we discuss their relevance to improving the reliability of individualized estimates by minimizing measurement noise. Second, we review how targeted within-subject experiments, when combined with individualized analysis or modeling frameworks, can maximize signal. These improvements in signal-to-noise facilitated by precision designs can help boost prediction studies. We close by discussing the integration of precision approaches with large-sample consortia studies to leverage the advantages of both.