Respiratory viral infections in bone marrow transplant patients: insights from a tertiary care hospital in Rawalpindi, Pakistan.

IF 0.8 4区医学 Q3 MEDICINE, GENERAL & INTERNAL Journal of the Pakistan Medical Association Pub Date : 2024-10-01 DOI:10.47391/JPMA.10587

Noman Shakoor, Saifullah Khan Niazi, Eijaz Ghani, Raheel Iftikhar, Ali Rathore, Misbah Noor

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Abstract

Objective: To determine the incidence of respiratory viral infections in bone marrow transplant patients.

Methods: The prospective, descriptive, cross-sectional study was conducted at a tertiary care hospital in Rawalpindi, Pakistan, from September 2019 to August 2020, and comprised respiratory specimens from recipients of haematopoietic stem cell transplant. The specimens were collected in viral transport medium, and were then taken to the Department of Virology. Multiplex polymerase chain reaction was performed on the specimens to ascertain the incidence and prevalence of respiratory viruses. Data was analysed using SPSS 24.

Results: Of the 85 subjects, 53(62.35%) were males and 32(37.65%) were females. The overall median age was 20.0 years (interquartile range: 11.0-32.0 years). Respiratory viral infections were detected in 31(36.4%) specimens. Among them, human rhinovirus was detected in 12(38.7%) cases, respiratory syncytial virus in 5(16.1%), influenza A/H3 in 4(13%), human parainfluenza virus-1 in 3(9.7%), adenovirus in 2(6.4%), human parainfluenza virus-3 in 1(3.2%), human parainfluenza virus-4 in 1(3.2%) and human metapneumovirus in 1(3.2%) case. There were 2(6.4%) cases of co-infection.

Conclusions: More than one-third recipients of haematopoietic stem cell transplant were found to have respiratory viral infections, highlighting the importance of employing multiplex respiratory polymerase chain reaction in early diagnosis and treatment of such infections.

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骨髓移植患者的呼吸道病毒感染：来自巴基斯坦拉瓦尔品第一家三级医院的启示。

目的：确定骨髓移植患者呼吸道病毒感染的发生率：确定骨髓移植患者呼吸道病毒感染的发病率：这项前瞻性、描述性、横断面研究于 2019 年 9 月至 2020 年 8 月在巴基斯坦拉瓦尔品第的一家三级医院进行，研究对象包括造血干细胞移植受者的呼吸道标本。标本在病毒运输培养基中收集，然后送往病毒学部门。对标本进行多重聚合酶链反应，以确定呼吸道病毒的发生率和流行率。数据使用 SPSS 24 进行分析：在 85 名受试者中，53 名（62.35%）为男性，32 名（37.65%）为女性。总体年龄中位数为 20.0 岁（四分位数间距：11.0-32.0 岁）。31份（36.4%）标本检测到呼吸道病毒感染。其中，12 例（38.7%）检测到人类鼻病毒，5 例（16.1%）检测到呼吸道合胞病毒，4 例（13%）检测到甲型流感/H3，3 例（9.7%）检测到人类副流感病毒-1，2 例（6.4%）检测到腺病毒，1 例（3.2%）检测到人类副流感病毒-3，1 例（3.2%）检测到人类副流感病毒-4，1 例（3.2%）检测到人类偏肺病毒。有 2 例（6.4%）合并感染：结论：超过三分之一的造血干细胞移植受者被发现患有呼吸道病毒感染，这凸显了采用多重呼吸道聚合酶链反应来早期诊断和治疗此类感染的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Pakistan Medical Association Medicine-General Medicine

CiteScore

1.10

自引率

11.10%

发文量

983

审稿时长

3-6 weeks

期刊介绍： Primarily being a medical journal, JPMA publishes scholarly research focusing on the various fields in the areas of health and medical education. It publishes original research describing recent advances in health particularly clinical studies, clinical trials, assessments of pathogens of diagnostic importance, medical genetics and epidemiological studies. Review articles highlighting importance of various issues in the domain of public health, drug research and medical education are also accepted. As a leading journal of South Asia, JPMA remains cognizant of the recent advances in the rapidly growing fields of biomedical sciences, it invites and encourages scholars to write short reviews and invited editorials on the emerging issues. We particularly aim to promote health standards of developing countries by encouraging manuscript submissions on issues affecting the public health and health delivery services.