The role of vagal nerve stimulation on psychosocial associated disorders in refractory epilepsy patients.

IF 0.8 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL Journal of the Pakistan Medical Association Pub Date : 2024-10-01 DOI:10.47391/JPMA-BAGH-16-37
Mohamed Abdul Jalil Al-Tamimi
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Abstract

Objective: To determine the effects of vagal nerve stimulation on cognition and epilepsy-associated psychosocial problems in patients with intractable epilepsy, and to assess their relation to seizure decline.

Methods: The longitudinal study was conducted at Saad Al-Witry Neurosciences Hospital, Baghdad, Iraq, from December 2015 to December 2020, and comprised refractory epilepsy cases with implanted vagal nerve stimulation devices. They were subjected to pre- and post-implantation epilepsy protocol assessment with added neuropsychological evaluation using the Mini-Mental State Examination system. Each case was followed up for 2 years post-implantation. Descriptive data regarding patient records of age, seizure nature, mental functioning level, and vagal nerve stimulation insertion was noted. Data was analysed using SPSS 21.

Results: Of the 150 patients, 75(50%) each were males and females, with 70(46.7%) aged <10 years at the time of surgery. Overall, 80(53.3%) patients had partial seizures with secondary generalisation, 70(46.7%) had refractory seizure attacks for <5 years, 78(52%) had attack frequency of 2-5 per day. All 150(100%) patients had had vagal nerve stimulation for >2 years. Post-intervention, 80(53.3%) patients had <2 attacks per day. Mini-Mental State Examination score was >25 in 35(23.3%) patients which post-intervention rose to 64(42.7%).

Conclusions: There was evidence of improvement with respect to patient characteristics predictive of vagal nerve stimulation-related cognition and neuropsychological responsiveness in refractory epilepsy.

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迷走神经刺激对难治性癫痫患者心理社会相关障碍的作用。
目的确定迷走神经刺激对难治性癫痫患者认知能力和癫痫相关社会心理问题的影响,并评估其与癫痫发作下降的关系:这项纵向研究于2015年12月至2020年12月在伊拉克巴格达萨阿德-维特里神经科学医院进行,研究对象包括植入迷走神经刺激装置的难治性癫痫病例。他们接受了植入前和植入后的癫痫方案评估,并使用迷你精神状态检查系统进行了神经心理学评估。每个病例都接受了植入后两年的随访。研究人员记录了患者的年龄、癫痫发作性质、精神功能水平和迷走神经刺激植入情况等描述性数据。数据使用 SPSS 21 进行分析:在 150 名患者中,男性和女性各占 75 人(50%),其中 70 人(46.7%)的年龄为 2 岁。干预后,80 名患者(53.3%)中有 35 名患者(23.3%)有 25 例,干预后增至 64 例(42.7%):有证据表明,在难治性癫痫患者中,预测迷走神经刺激相关认知和神经心理学反应的患者特征有所改善。
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来源期刊
CiteScore
1.10
自引率
11.10%
发文量
983
审稿时长
3-6 weeks
期刊介绍: Primarily being a medical journal, JPMA publishes scholarly research focusing on the various fields in the areas of health and medical education. It publishes original research describing recent advances in health particularly clinical studies, clinical trials, assessments of pathogens of diagnostic importance, medical genetics and epidemiological studies. Review articles highlighting importance of various issues in the domain of public health, drug research and medical education are also accepted. As a leading journal of South Asia, JPMA remains cognizant of the recent advances in the rapidly growing fields of biomedical sciences, it invites and encourages scholars to write short reviews and invited editorials on the emerging issues. We particularly aim to promote health standards of developing countries by encouraging manuscript submissions on issues affecting the public health and health delivery services.
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