Research progress on the role and mechanism of circular RNA in drug resistance of head and neck squamous cell carcinoma.

IF 4.6 Q1 ONCOLOGY 癌症耐药(英文) Pub Date : 2024-09-02 eCollection Date: 2024-01-01 DOI:10.20517/cdr.2024.57
Hongli Zeng, Junshang Ge, Yi Meng, Qian Wang, Mei Yang, Zhaoyang Zeng, Wei Xiong, Xuyu Zu
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Abstract

Drug resistance in tumors constitutes a significant obstacle to tumor therapy. Head and neck squamous cell carcinoma (HNSCC) presents a major challenge due to its deep anatomical location, limited space, and complex structure. These factors complicate surgical procedures and hinder the effectiveness of chemoradiotherapy, leading to poor prognosis and reduced quality of life. However, there is hope in the form of circular RNAs (circRNAs), non-coding RNA molecules with a closed-loop structure that exhibits superior stability and resistance to degradation compared to linear RNAs. Recent advances in high-throughput sequencing and bioinformatics technology revealed that circRNAs participate in tumor proliferation, invasion, migration, and drug resistance. This review aims to summarize current research progress on the involvement of circRNAs in drug resistance of HNSCC and provide valuable insights for the prevention and mitigation of drug resistance in HNSCC.

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环状 RNA 在头颈部鳞状细胞癌耐药性中的作用和机制的研究进展。
肿瘤的耐药性是肿瘤治疗的一大障碍。头颈部鳞状细胞癌(HNSCC)因其解剖位置深、空间有限、结构复杂而成为一大难题。这些因素使手术过程复杂化,阻碍了化放疗的效果,导致预后不良和生活质量下降。然而,环状 RNA(circRNA)的出现让人们看到了希望。环状 RNA 是一种非编码 RNA 分子,具有闭环结构,与线性 RNA 相比,具有更高的稳定性和抗降解性。高通量测序和生物信息学技术的最新进展表明,circRNAs 参与了肿瘤的增殖、侵袭、迁移和耐药性。本综述旨在总结目前关于 circRNAs 参与 HNSCC 耐药性的研究进展,为预防和缓解 HNSCC 耐药性提供有价值的见解。
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