Hanadi Chammout, Delia L Adkins, Aleece K Al-Olimat, Zeinab Alsaad, Beatrice M Altopp, Tuqa Amer, Feyi O Apampa, Gwendolyn R Avery, Isaac I Bazzi, Emilia D Beck, Elise L Beier, B Shafer Belisle, Lane Benton, Madison M Bolyard, Olivia E Brain, Eldon T Buckner, Shria Roy Chowdhury, Jennifer R Cifranic, Liam Cleary, Tyler R Clum, Autumn M Cruz, Meghan V DeGray, Isabel L Echeverry, Haya El Dana, Sarah K Elkadri, Paige L Estep, Luke R Falke, Hannah J Foor, Anika S Gullapalli, Sandro S Hakim, Hussein B Hazime, Lauren E Heininger, Emma G Hoeft, Lauren M James, Yeowon Jeon, Megan R Johnson, Laine P Jordan, Zayd Khan, Sydney K Kochensparger, Fadi J Koria, Ruby M Krasnow, Veronica Lilly, Eileen Lim, Ian T MacCormack, Andriy Malesh, Mikayla G Mariano, Audrey C Mentzer, Katelyn H Messner, Katlyn C Myers, Emily R Newman, Annie M Richters, Liliana Romero, Adam Rotem, Reese J Saho, Kaname Sawaki, Ashley N Selders, Elizabeth Shockney, Farah A Sobh, Isabelle F Speiser, Breanna M Sproul, Veronica J Sroufe, Antonia Tollkuci, Cassandra C Trevino, Megan A Vapenik, Erin M Wagner, Kayla L Bieser, Jamie L Siders, Justin R Thackeray, Jacob D Kagey
{"title":"<i>G.3.2</i> is a novel allele of the gene <i>connector enhancer of ksr</i> ( <i>cnk</i> ) in <i>Drosophila melanogaster</i>.","authors":"Hanadi Chammout, Delia L Adkins, Aleece K Al-Olimat, Zeinab Alsaad, Beatrice M Altopp, Tuqa Amer, Feyi O Apampa, Gwendolyn R Avery, Isaac I Bazzi, Emilia D Beck, Elise L Beier, B Shafer Belisle, Lane Benton, Madison M Bolyard, Olivia E Brain, Eldon T Buckner, Shria Roy Chowdhury, Jennifer R Cifranic, Liam Cleary, Tyler R Clum, Autumn M Cruz, Meghan V DeGray, Isabel L Echeverry, Haya El Dana, Sarah K Elkadri, Paige L Estep, Luke R Falke, Hannah J Foor, Anika S Gullapalli, Sandro S Hakim, Hussein B Hazime, Lauren E Heininger, Emma G Hoeft, Lauren M James, Yeowon Jeon, Megan R Johnson, Laine P Jordan, Zayd Khan, Sydney K Kochensparger, Fadi J Koria, Ruby M Krasnow, Veronica Lilly, Eileen Lim, Ian T MacCormack, Andriy Malesh, Mikayla G Mariano, Audrey C Mentzer, Katelyn H Messner, Katlyn C Myers, Emily R Newman, Annie M Richters, Liliana Romero, Adam Rotem, Reese J Saho, Kaname Sawaki, Ashley N Selders, Elizabeth Shockney, Farah A Sobh, Isabelle F Speiser, Breanna M Sproul, Veronica J Sroufe, Antonia Tollkuci, Cassandra C Trevino, Megan A Vapenik, Erin M Wagner, Kayla L Bieser, Jamie L Siders, Justin R Thackeray, Jacob D Kagey","doi":"10.17912/micropub.biology.001290","DOIUrl":null,"url":null,"abstract":"<p><p>Genetic screens in <i>Drosophila melanogaster</i> have long been used to identify genes found in a variety of developmental, cellular, and behavioral processes. Here we describe the characterization and mapping of a mutation identified in a conditional screen for genetic regulators of cell growth and cell division. Within a Flp/FRT system, mutant <i>G.3.2</i> results in a reduction of mutant tissue and a rough eye phenotype. We find that <i>G.3.2</i> maps to the gene <i>cnk</i> , providing further support that <i>cnk</i> is a critical gene in <i>Drosophila</i> eye development. This mutant was characterized, mapped and sequenced by undergraduate students within the Fly-CURE consortium.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2024 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467748/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"microPublication biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17912/micropub.biology.001290","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Genetic screens in Drosophila melanogaster have long been used to identify genes found in a variety of developmental, cellular, and behavioral processes. Here we describe the characterization and mapping of a mutation identified in a conditional screen for genetic regulators of cell growth and cell division. Within a Flp/FRT system, mutant G.3.2 results in a reduction of mutant tissue and a rough eye phenotype. We find that G.3.2 maps to the gene cnk , providing further support that cnk is a critical gene in Drosophila eye development. This mutant was characterized, mapped and sequenced by undergraduate students within the Fly-CURE consortium.
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