What to expect following targeted muscle reinnervation/regenerative peripheral nerve interface: Pain outcomes in an amputee population

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Abstract

Targeted muscle reinnervation (TMR) and regenerative peripheral nerve interface (RPNI) have shown promise in improving and/or preventing neuropathic pain and reducing narcotic use in amputees. However, anecdotally, some patients experience an increase in pain in the first few months post-operatively. This study explored the pain trajectory of 22 upper and lower extremity amputees following their TMR and/or RPNI procedure in their first post-operative year, with a focus on the patterns of recovery in the first few months. Our study found an overall decrease in the amount of pain and pain medication use at various time points post-operatively. Of note, several individuals had an increase in pain or required an increase in pain medications in the first three months. Different outcomes for patients who underwent primary versus secondary surgery were seen, which has been observed in other studies. Further prospective studies are warranted to evaluate these trends in pain after TMR or RPNI surgery in individuals with major limb amputations.
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定向肌肉神经再支配/再生外周神经接口后的预期效果:截肢者的疼痛结果。
靶向肌肉神经再支配(TMR)和再生周围神经接口(RPNI)在改善和/或预防截肢者的神经性疼痛和减少麻醉剂使用方面已显示出前景。然而,据传闻,一些患者在术后头几个月疼痛加剧。本研究探讨了 22 名上肢和下肢截肢者在接受 TMR 和/或 RPNI 术后第一年的疼痛轨迹,重点关注术后最初几个月的恢复模式。我们的研究发现,在术后的不同时间点,疼痛和止痛药物的使用量总体上有所减少。值得注意的是,有几个人在头三个月疼痛加剧或需要增加止痛药物。接受初次手术和二次手术的患者结果不同,这在其他研究中也有观察到。有必要进一步开展前瞻性研究,以评估大肢截肢患者在接受 TMR 或 RPNI 手术后疼痛的趋势。
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来源期刊
CiteScore
3.10
自引率
11.10%
发文量
578
审稿时长
3.5 months
期刊介绍: JPRAS An International Journal of Surgical Reconstruction is one of the world''s leading international journals, covering all the reconstructive and aesthetic aspects of plastic surgery. The journal presents the latest surgical procedures with audit and outcome studies of new and established techniques in plastic surgery including: cleft lip and palate and other heads and neck surgery, hand surgery, lower limb trauma, burns, skin cancer, breast surgery and aesthetic surgery.
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Editorial Board The impact of cosmetic tourism across one year on an NHS breast surgery unit The roles of extracranial intravascular lesion, vasodilation-induced neural entrapment, and arteriolysis in migraine treatment Nail reconstruction using an osteo-onychocutaneous flap with the dorsal digital artery of the hallux as the pedicle: Techniques and anatomical insights Reduction mammaplasty relieves depression in women with macromastia: A systematic review
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