{"title":"Giant Macrocycle Overcomes the Post-Treatment Phototoxicity of Photofrin through Host-Guest Complexation","authors":"Shujie Lin, Xiang Yu, Ziliang Zhang, Yahan Zhang, JunYi Chen, Chunju Li, Qingbin Meng","doi":"10.1039/d4cc04777j","DOIUrl":null,"url":null,"abstract":"Here we reported a supramolecular sequestration strategy to overcome the post-treatment phototoxicity of Photofrin via direct host-guest complexation. Robust binding potency of a giant pentaphen[3]arene derivative could favor to suppress sunlight-induced skin damage through decreasing the ability of engulfed Photofrin in photosensitizing the formation of singlet oxygen.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Communications","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d4cc04777j","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Here we reported a supramolecular sequestration strategy to overcome the post-treatment phototoxicity of Photofrin via direct host-guest complexation. Robust binding potency of a giant pentaphen[3]arene derivative could favor to suppress sunlight-induced skin damage through decreasing the ability of engulfed Photofrin in photosensitizing the formation of singlet oxygen.
期刊介绍:
ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.